LIFE-CYCLE OF THE VACCINIA VIRUSLIFE-CYCLE OF THE VACCINIA VIRUS.doi:10.1016/S0140-6736(00)30417-2NoneElsevierLancet
Throughout its life cycle, VV replicates exclusively in the cytoplasm of infected cells, although the presence of a nucleus is required in order for the... DE Hruby,LA Guarino,JR Kates - 《Journal of Virology》 被引量: 186发表: 1979年 The vaccinia virus I1 protein is essential for the...
their molecular mechanisms (Cotchin1962,1976) and discovering novel therapeutics against (Misdorp1996). The life cycle, genomic structures, viral proteins, and pathophysiology of bovine viruses studied in vitro paved the way for understanding the human counterparts such as Hepatitis C virus (HCV) tha...
MAITLAND and MAITLAND have previously described the cultivation of vaccinia virus in a mixture of minced hen's kidney, serum and Tyrode's solution; and other workers have succeeded in growing vaccinia, and other filtrable viruses, by this method, sometimes substituting tissue and serum from the ...
Life Cycle of a VirusBecause viruses are not alive, their life cycle is largely dependent on the host. It involves the following phases/steps:Attachment Once the virus gets into the body, it uses specific attachment proteins to bind receptors on the surface of the cell of the host. ...
Vaccinia virus (VACV), the prototype member of thePoxviridae, replicates in the cytoplasm of an infected cell. The catalytic subunit of the DNA polymerase E9 binds the heterodimeric processivity factor A20/D4 to form the functional polymerase holoenzyme. Here we present the crystal structure of fu...
1f) and within each genome type (Fig. 1g) are largely involved in fundamental aspects of the viral life cycle. These include the single jellyroll fold, which comprises viral capsids and is present in viruses of many genome types. The double jellyroll fold also comprises viral capsids, ...
1992. Insertional inactivation of the vaccinia virus 32-kilodalton gene is associated with attenuation in mice and reduction of viral gene expression in ... JR Rodriguez,D Rodriguez,M Esteban - 《Journal of Virology》 被引量: 45发表: 1992年 Cytopathogenicity of a pestivirus correlates with a ...
Vaccinia virus (VACV), the prototype member of the Poxviridae, replicates in the cytoplasm of an infected cell. The catalytic subunit of the DNA polymerase E9 binds the heterodimeric processivity factor A20/D4 to form the functional polymerase holoenzyme
To investigate whether RNA 5′AU sequence-specific recognition by nsP1 affects the capping activity (Figure 2), the reactions were set up with 1 μM 12-mer recipient RNAs of the sequence from either the CHIKV genome 5′ end (labeled as pppAU-10) or the Dengue virus genome 5′ end (...