Evidence of the importance of natural products in the discovery of leads for the development of drugs for the treatment of human diseases is provided by the fact that close to half of the best selling pharmaceuticals in 1991 were either natural products or their derivatives.4 In this regard, ...
Today, three key factors stand out: a global increase in sepsis cases [1,14], significant healthcare challenges from sepsis-related mortality and morbidity [2,15] and a notably rise in very old patients with sepsis due to the aging of population [16,17]. Addressing these challenges requires...
Each IL-6 family member elicits responses essential to the physiological control of immune homeostasis, haematopoiesis, inflammation, development and metabolism. Accordingly, distortion of these cytokine activities often promotes chronic disease and cancer; the pathological importance of this is exemplified ...
Intra-operative embolism is the main cause of stroke in patients undergoing surgical repair of the DTA, emphasizing the importance of precautions during the operative period. Debris from aortic atheroma/thrombus can result in an embolic ischaemic stroke and the release of debris should be prevented ...
This cohort study evaluates the association of implementation of the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) with sepsis treatment
The current approach is to develop better diagnostics to identify and treat sepsis early, and understand the immune profile (activation versus suppression) in this disease. BARDA's Division of Research, Innovation, and Ventures (DRIVe) is establishing unique public-private partnerships that could ...
Respiratory diseases, marked by structural changes in the airways and lung tissues, can lead to reduced respiratory function and, in severe cases, respiratory failure. The side effects of current treatments, such as hormone therapy, drugs, and radiothera
Meaning Although suggestive of benefit for hydrocortisone in patients with severe COVID-19, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Abstract Importance Evidence regarding corticosteroid use for severe corona...
Consensus-meeting participants were invited to comment on the importance of each item and whether the item should be included in the AI extension. In addition, participants were invited to comment on the wording of the explanatory text accompanying each item and the position of each item relative...
Incorrect condition of fallopian tubes occurs as a result of lack of patency and mobility which are most often caused by untreated sexually transmitted infections, sepsis, or complications of unsafe abortion or abdominal surgery. The main causes of uterine disorders are endometriosis, uterine fibroids,...