Furthermore, two phase I clinical trials using anti-TGFβ monoclonal antibodies have shown preliminary evidence of antitumor activity in patients with advanced melanoma [131], [132]. The importance of ECM stiffness in creating a permissive tumor microenvironment is also well illustrated in aggressive ...
The mucosal tissues of the gastrointestinal, respiratory, reproductive, and urinary tracts, and the surface of the eye present an enormous surface area to the exterior environment. All of these tissues are covered with resident microbial flora, which vary considerably in composition and complexity. Mu...
2. Aging and immunosenescence: current knowledge and the biases of previous studies based on blood 3. The tight connection between immune cells and the ECM 4. Immunosenescence, cell mobility and age-related changes in the ECM: the “mesh” connection 5. Consequences of the lower mobility of T...
Tissue engineering is a multidisciplinary field that seeks to promote the functional and morphological reconstruction of tissues and organs after injury. Its components encompass seeding cells, biomaterial scaffolds, dynamic culture conditions, and micro-physiological environment simulations. By creating artifici...
ECM remodelling, and direct cell-cell contacts [7]. They respond dynamically to changes in mechanical, chemical, and electrical signals by activating cell proliferation and modifying ECM, which regulate myocardial growth, homeostasis, and cardiac repair [29]. CFs are the primary producers of ECM ...
Collagen formation, function and role in kidney disease Article 15 November 2024 Introduction Fibrillar collagens I, II and III are the major components of the extracellular matrix (ECM). They provide tissues with tensile strength but also constitute active scaffolds, presenting sites for cell adhes...
These studies collectively emphasize the importance of studying intercellular crosstalk using human cell-based models to gain insights into neurodegenerative diseases, bridging the gap between physiological and pathological aspects of the human brain. However, despite the growing research on intercellular cross...
All of the experts underlined the importance of generating organoids (or spheroids) from patient tissues and biopsies allowing for personally tailored medicine. “Organoids hold great promise for toxicological drug and compound screening and one day could reduce the use of non-human animals for the...
The importance of restoring functional CMs for post-infarction repair is self-evident because they provide the mechanical force needed for contraction. In a rat model of myocardial infarction (MI), measurements of cardiac function and remodeling were significantly better when implanted fibrin gel-based...
between the tissues derived from the inner cell mass and the trophoblast—however, the origin of these cells remains unclear5. Recent work in mouse embryos established conditions amenable to human embryo in vitro culture through implantation, opening up this developmental black box6,7,8. However, ...