Of note, specific molecular subtypes according stroma organization have been described and classified as “normal” and “activated”, with the latter showing a worst prognosis [15]. Pancreatic CAFs (pCAFs) are responsible of ECM deposition, immune evasion/exclusion and support tumor growth ...
integrins activate downstream pathways, so-called ‘outside-in’ and ‘inside-out’ signaling, through ECM-cytoskeleton linkers formed after cell adhesion [1,2]. Integrins are cell membrane protein receptors. α subunit consists of αA domain, β-propeller...
adapt to stress, injury, or growth, disruption in the balance of ECM synthesis and degradation, driven by paracrine or autocrine signaling, can lead to pathological remodeling. Meanwhile, direct intercellular connections between CMs and CFs, mediated by connexins, enable the exchange of molecular and...
A fundamental componentpertaining to heart valves is its dynamic behavior.Specific fluid-induced shears stress patterns may play acritical role in up-regulating ECM secretion by progenitor cell sources such as bone marrow derived stem cells [2]and increasing the possibility of cell differentiationtowards...
The extracellular matrix (ECM) of tissues is composed of a complex network of proteins, glycoproteins and glycosaminoglycans that surround cells. Purified components of the ECM have been widely employed in the design of tissue engineering scaffolds where they provide a similar cell niche to the nativ...
our results suggest that there are other trade-offs that could be of comparable importance in shaping tumor gene expression. We suggest trade-offs between organizing metabolism to grow on glucose versus using lipids for growth, and between rapid cell division, immune evasion, and tissue remodeling....
via TLR4, promote the formation of a vascular niche by secreting NO and TNF to induce expression of niche components in ECs. The results reveal a critical crosstalk within vascular niches, and underscore the importance of extracellular matrix proteins as regulators of the microenvironment in ...
TAMs promote tumor progressionin different ways, such asstimulating angiogenesis and lymphangiogenesis, stimulating both cancer cell proliferation and epithelial–mesenchymal transition, limiting the efficacy of therapies, remodeling the ECM, promoting metastasis, and inducing immunosuppression of anti-tumor effec...
Tissue engineering combines cell biology and material science to construct tissues or organs for disease modeling, drug testing, and regenerative medicine. The cell sheet is a newly developed tissue engineering technology that has brought about scaffold-
In the case of COVID-19-associated brain damage, it is of particular importance for anti-inflammatory agents and small RNA to deliver their therapeutic effects. Also, there is pre-clinical and experimental evidence for the effectiveness of mesenchymal stem cells (MSC)-EVs in stimulating endogenous...