The past two centuries have witnessed an unprecedented rise in human life expectancy. Sustaining longer lives with reduced periods of disability will require an understanding of the underlying mechanisms of ageing, and genetics is a powerful tool for identifying these mechanisms. Large-scale genome-wide...
Defining the genetic architecture of a complex trait or disease is central to the scientific and clinical goals of human genetics, which are to understand disease aetiology and aid in disease screening, diagnosis, prognosis and therapy. Recent technological advances have enabled genome-wide association...
While there is no ground truth for the human transcriptome, we used the Ensembl v94 (Release 94, October 2018) human genome reference annotation [18] as a reference to understand how our results compare to current annotations. We identified the number of gene loci and transcript models from ...
These miRNAs are coded by separate genes that are localized in the nonprotein coding part of the genome. MicroRNAs predict to regulate about 30%–60% of human genes (Griffiths-Jones et al., 2008, Malumbres, 2013). These small noncoding RNAs bind their target messenger RNAs (mRNAs) in ...
s milk to the neonatal rumen possibly is the initial and primary source of the rumen resistome. Feeding strategies or nutritional practices in young ruminants, such as solid diet supplementation manipulating the microbiome, can influence the rumen resistome and ARG horizontal transfer. The current ...
The 2 genome-wide significant loci previously identified in the CONVERGE study20 did not show evidence of association in any of the other data sets of cohorts with East Asian ancestry included in this study (eFigure 5 and eTable 7 in Supplement 2). It is worth noting that the effect ...
Microbiome-metabolome studies of the human gut have been gaining popularity in recent years, mostly due to accumulating evidence of the interplay between gut microbes, metabolites, and host health. Statistical and machine learning-based methods have been
The gymnosperm Welwitschia mirabilis belongs to the ancient, enigmatic gnetophyte lineage. It is a unique desert plant with extreme longevity and two ever-elongating leaves. We present a chromosome-level assembly of its genome (6.8 Gb/1 C) together
Information storage and retrieval is essential for all life. In biology, information is primarily stored in two distinct ways: the genome, comprising nucleic acids, acts as a foundational blueprint and the epigenome, consisting of chemical modifications
to recreate the dodo genome. he added, "i've no idea whether the project will work as they claim, but the question is not just 'can you do this', but 'should you do it?'… i'm not sure what purpose it serves, and whether ...