We tested their recombination activity in human cells, classifying them as landing pad, genome-targeting or multi-targeting LSRs. Overall, we achieved up to seven-fold higher recombination than Bxb1 and genome integration efficiencies of 40–75% with cargo sizes over 7 kb. We also demonstrate...
The past two centuries have witnessed an unprecedented rise in human life expectancy. Sustaining longer lives with reduced periods of disability will require an understanding of the underlying mechanisms of ageing, and genetics is a powerful tool for identifying these mechanisms. Large-scale genome-wide...
B. dentium, which is commonly found in the human oral microbiome21, had increased abundance and prevalence in the gut with age22. While two dozen of other bacterial species have been identified as age-associated23, their associations with age in CRC patients were weak, suggesting that CRC ...
I was not much involved in the discussion and debate about initiating a program to determine the base-pair sequence of the human genome, until the idea surfaced publicly. As I recall the genesis of the Human Genome Project, the idea for sequencing the human genome was initiated independently ...
Microbiome-metabolome studies of the human gut have been gaining popularity in recent years, mostly due to accumulating evidence of the interplay between gut microbes, metabolites, and host health. Statistical and machine learning-based methods have been
Evolutionary rates are not constant across the human genome but genes in close proximity have been shown to experience similar levels of divergence and selection. The higher-order organisation of chromosomes has often been invoked to explain such phenome
Or does it mean improving the human ___ of living? Today, when people say growth, they mean GDP, a measure that is over 70 years old. Actually GDP demonstrates negative ___ for biodiversity, as this “growth” measures only money inflows while far more important is the balance sheet,...
Neanderthal DNA — between 1-3% of their total. However, one study on a sample from a modern human who lived in what is now Romania between 37,000 and 42,000 years ago contained about 6-9% percent Neanderthal genetic material, more than any other modern human genome that has yet been ...
Defining the genetic architecture of a complex trait or disease is central to the scientific and clinical goals of human genetics, which are to understand disease aetiology and aid in disease screening, diagnosis, prognosis and therapy. Recent technological advances have enabled genome-wide association...
Lipids are the most abundant but poorly explored components of the human brain. Here, we present a lipidome map of the human brain comprising 75 regions, including 52 neocortical ones. The lipidome composition varies greatly among the brain regions, affe