Presents a study which examined the activity of the HIV-1 rev protein. How HIV-1 is regarded; Reference to the binding of infectious virions to cellular receptors on the surface of susceptible cells through the envelope (Env) glycoproteins; Information on the exemplification of the least complex...
The impact of the Rev protein of the () on , intranuclear distribution, and gene expression was examined for two Rev-dependent expression systems by means of fluorescence in situ hybridization, immunofluorescence, S1 nuclease protection, and functional assays. In the pgTat expression system, which ...
Posttranscriptional regulation by the HIV-1 Rev protein - Cullen - 1998 () Citation Context ...n. We observed a reproducible reduction in the export of genomic RNA from the nucleus in the mutant virus. Whilst it was less marked than published effects on transport caused by mutation of the ...
The humoral immune response after acute infection with HIV-1 is delayed and ineffective. The HIV-1 envelope protein gp120 binds to and signals through integrin α4β7on T cells. We found that gp120 also bound to and signaled through α4β7on naive B cells, which resulted in an abortive ...
It has previously been shown that interaction of eukaryotic initiation factor 5A (eIF-5A) with the Rev trans-activator protein of HIV-1 mediates the transport of unspliced or incompletely spliced viral mRNAs across the nuclear envelope. Consequently, mutants of eIF-5A block Rev function and thereb...
HIV-1 viral protein R (Vpr) regulates viral replication and cellular proliferation in T cells and monocytoid cells in vitro. Among the putative accessory genes of HIV-1, the 96-amino-acid virion-associated vpr gene product has been described to have several novel biological activ... V Ayyav...
Nucleic acid recognition and antiviral activity of 1,4-substituted terphenyl compounds mimicking all faces of the HIV-1 Rev protein positively-charged α-helix Cristina Medina-Trillo, Daniel M. Sedgwick, Lidia Herrera, Manuela Beltrán, Ángela Moreno, Pablo Barrio, Luis. M. Bedoya, ...
Several viral proteins, including nucleocapsid protein, integrase, Vif, Tat, and Nef have been proposed to act as cofactors of HIV-1 reverse transcription. Using two viral RNA probes, one overlapping the primer-binding site (PBS) and the other representing the ribosomal frameshifting signal (FS)...
Replication of human immunodeficiency virus type 1 (HIV-1) in non-dividing cells critically depends on import of the viral pre-integration complex into the nucleus. Genetic evidence suggests that viral protein R (Vpr) and matrix antigen (MA) are directly involved in the import process. An in ...
HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator The HIV-1 matrix (MA) protein contains two subcellular localization signals with opposing effects. A myristoylated N-terminus governs particle assembly at ... P Gallay,S ...