Target-controlled infusion (TCI) - a concept with a future: state-of-the-art, treatment recomm- endations and a look into the future[J].Anaesthesist, 2008, 57(3): 223-30.Schraag S, Kreuer S, Bruhn J, et al. Tar
Varveris DA, Morton NS (2002) Target controlled infusion of propofol for induc- tion and maintenance of anaesthesia using the paedfusor: an open pilot study. Paediatr Anaesth 12:589-593Varveris DA, Morton NS. Target controlled infusion of propofol for induction and maintenance of anaesthesia ...
Objective To study the effect of remifentanil given by target-controlled infusion(TCI) on the haemodynamic response to emergence from anesthesia and tracheal extubation.Methods Sixty ASA Ⅰ-Ⅱ female patients undergoing gynecological surgery were randomly assigned into two groups with 30 cases each: gro...
Clinical trials with pan-CDK inhibitors, such as flavopiridol, have demonstrated low levels of clinical activity and drug target selectivity. The reasons for their failure in the clinic include the absence of clear biomarkers for response and the lack of a clear therapeutic window. The selective CD...
In recent years, nonculture-dependent techniques, such as 16s rRNA sequencing and other metagenomic analysis are often used to understand the effect of intestinal microbiota; these have resulted in a quicker analyses of various intestinal microbiota, and help researchers achieve more accurate and useful...
Propofol was administered using a target-controlled infusion (TCI) pump to obtain constant effect site concentration as estimated by Marsh model. Under general anesthesia, remifentanil (1.0 μg/kg) and succinylcholine (1.5 mg/kg) were administered for ease of endotracheal intubation. Starting...
In: Kostrzewa RM (ed) Handbook of neurotoxicity. Springer, New York Google Scholar Bradshaw RA, Mobley W, Rush RA (2017) Nerve growth factor and related substances: a brief history and an introduction to the international NGF meeting series. Int J Mol Sci 18(6):1143. https://doi.org/...
CONCLUSIONS: The use of continuous HTS might achieve target sodium levels earlier compared to intermittent HTS. There was increased incidence of hypernatremia and hyperchloremia in continuous HTS groups. CLINICAL IMPLICATIONS: Continuous infusion of HTS may achieve sodium goals quicker but may require...
functionality of the BBB organoids was assessed by measuring transferrin-specific transcytosis. The authors use anti-transferrin receptor antibodies to cross the BBB-organoids, showing that transferrin-mediated transport is clathrin- dependent, which can help develop new drugs to target this crossing [...
Genome instability has been identified as one of the enabling hallmarks in cancer. DNA damage response (DDR) network is responsible for maintenance of genome integrity in cells. As cancer cells frequently carry DDR gene deficiencies or suffer from replic