Target-controlled infusion (TCI) delivers drugs in calibrated boluses to achieve and maintain a selected target plateau drug level (plasma or effect site). Interactive total intravenous anesthesia (iTIVA (TM)) smartphone software simulates TCI and employs 31 established pharmacokinetic models for 11 ...
Target controlled infusion of propofol for induction and maintenance of anaesthesia using the paedfusor: an open pilot study.Background: The aim of this study was to evaluate the ease of use and efficacy of the Paedfusor, a computer controlled propofol infusion device with software appropriate ...
Target-controlled infusion (TCI) drug delivery systems deliver intravenous drugs based on pharmacokinetic models. TCI devices administer a bolus, followed by exponentially declining infusions, to rapidly achieve and maintain pseudo-steady state drug concentrations in the plasma or at the site of drug ...
Objective To study the effect of remifentanil given by target-controlled infusion(TCI) on the haemodynamic response to emergence from anesthesia and tracheal extubation.Methods Sixty ASA Ⅰ-Ⅱ female patients undergoing gynecological surgery were randomly assigned into two groups with 30 cases each: gro...
Objective To evaluate the effect of propofol target(controlled) infusion(TCI) on stress response during epidural anesthesia.Methods Thirty ASA Ⅰ-Ⅱ patients undergoing hysterectomy were randomly allocated into group Ⅰ(propofol TCI of 1.5 μg/ml during operation) and group Ⅱ(without propofol).HR ...
This review will focus on the history of monoclonal antibody development – how it has increasingly moved away from using laborious animal models to a more effective phage display system, some of the major drawbacks from a clinical and economical point of view and future innovations that are curre...
Clinical trials with pan-CDK inhibitors, such as flavopiridol, have demonstrated low levels of clinical activity and drug target selectivity. The reasons for their failure in the clinic include the absence of clear biomarkers for response and the lack of a clear therapeutic window. The selective CD...
A short history of nitroglycerine and nitric oxide in pharmacology and physiology Clin Exp Pharmacol Physiol, 27 (2000), pp. 313-319 View in ScopusGoogle Scholar 11 C.A. den Uil, J.J. Brugts Impact of intravenous nitroglycerin in the management of acute decompensated heart failure Curr Heart...
Drug delivery technologies have enabled the development of many pharmaceutical products that improve patient health by enhancing the delivery of a therapeutic to its target site, minimizing off-target accumulation and facilitating patient compliance. As
1.1. A Piece of History In 1930, R. Kurzrok and C. C. Lieb demonstrated that the uterine endometrium contracted and relaxed rhythmically after exposure to semen [1]. In 1939, Ulf von Euler stated that this contraction was due to the action of an unknown unsaturated lipid, which he called...