We found that mutant versions of p53 had contrasting effects in different segments of the gut: in the distal gut, mutant p53 had the expected oncogenic effect; however, in the proximal gut and in tumour organoid
physiological associations and direct interactions with MLL4 and promotes the enhancer binding of MLL4, which is required for TNFα-inducible H3K4me1 and histone H3 lysine 27 acetylation (H3K27ac) levels, enhancer-derived transcript (eRNA) synthesis, and mutant p53-dependent target gene activation...
Rangel LP, Costa DC, Vieira TC, Silva JL (2014) The aggregation of mutant p53 produces prion-like properties in cancer. Prion 8: 75-84.Rangel LP, Costa DC, Vieira TC, Silva JL.. The aggregation of mutant p53 produces prion-like properties in cancer . Prion (2014) 8 ( 1 ):75–...
p53mutations occur in ~50% of human cancers and are commonly associated with poor therapy responses and poor patient outcomes [82]. People with Li-Fraumeni syndrome that inherit one mutantp53allele and one WTp53allele have an ~50% likelihood of developing cancer by the age of 35 and a ~90...
recruitment, the synthesis of enhancer RNAs, and the activation of tumor-promoting genes. Collectively, these findings establish a mechanism by which chronic TNF-α signaling orchestrates a functional interplay between mutant p53 and NFκB that underlies altered patterns of cancer-promoting gene ...
Interestingly, mutant p53 ablation attenuates the activity of NF-κ B and renders cancer cells susceptible to killing by TNF. Finally, we observed a close correlation between the high frequency of p53 mutations and the elevated expression of NF-κ B target genes in breast tumors. Therefore, our...
TP53 is the most frequently mutated gene in human cancer, and small-molecule reactivation of mutant p53 function represents an important anticancer strategy. A cell-based, high-throughput small-molecule screen identified chetomin (CTM) as a mutant p53 R175H reactivator. CTM enabled p53 to transac...
Gain of function of mutantp53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation. Cancer Cell 2006;10:191–202. Article Google Scholar Ferraiuolo M, Di Agostino S, Blandino G, Strano S. Oncogenic Intra-p53 Family Member Interactions in...
TP53 is the most frequently mutated gene in cancers. Mutations lead to loss of p53 expression or expression of a mutant protein. Mutant p53 proteins commonly lose wild-type function, but can also acquire novel functions in promoting metastasis and chemoresistance. Previously, we uncovered a role ...
Thus, these data suggest that restoration of miR-130b may have therapeutic value in tumors expressing mutant p53. RESULTS Mutant p53 GOF contributes to EMT in EC cells Although mutant p53 GOF has been shown to promote EMT by upregulating Twist in prostate cancer cells,10 to date, the role ...