Compartmentalization of the gut microbiota is thought to be important to system function, but the extent of spatial organization in the gut ecosystem remains poorly understood. Here, we profile the murine colonic microbiota along longitudinal and lateral axes using laser capture microdissection. We found...
(also known as the brain-gut axis), is thought to be involved in many regular functions and systems within the healthy body, in addition to the pathogenesis of many diseases from neurological and degenerative conditions to autoimmune diseases. The gut-brain axis is now being investigated as a ...
The gut microbiome is known to be sensitive to changes in the immune system, especially during autoimmune diseases such as Multiple Sclerosis (MS). Our study examines the changes to the gut microbiome that occur during experimental autoimmune encephalomyelitis (EAE), an animal model for MS. We co...
This relationship, dubbed the microbiota-gut-brain axis, is thought to be involved in many aspects of homeostasis in addition to the pathogenesis of several diseases, ranging from neurological and degenerative conditions to autoimmune diseases. This cross-journal collection brings together both human ...
There is increasing evidence showing that the dynamic changes in the gut microbiota can alter brain physiology and behavior. Cognition was originally thought to be regulated only by the central nervous system. However, it is now becoming clear that many non-nervous system factors, including the gut...
through its capacity to produce bile acid metabolites distinct from the liver (i.e., secondary bile acids), can be thought of as an “endocrine organ” with the potential to alter host physiology, perhaps in their own favor. The term “sterolbiome” [74] describes the genetic potential of...
derived metabolites directly, and vagus nerve trafficked gut-derived hormones can then alter phenotype of the blood brain barrier and central nervous system cell types (microglia, astrocytes, neurons), which can then modulate amyloidosis, tauopathy, and neurodegeneration and contribute to disease ...
The vagus nerve is the body’s longest nerve, relaying messages between the intestines and the brain while touching many organs in between. It is thought to be a major way that psychobiotics exert influence on the brain. Dr. Ted Dinan’sresearch supports this. ...
It is evident that the compositional and proportional differences in the gut microbiome are associated with the development of AID via an immunomodulatory effect of the gut microbiome. The gut microbiome may contribute to the development, persistence, and severity of AID via immunologic, metabolic, an...
derived metabolites directly, and vagus nerve trafficked gut-derived hormones can then alter phenotype of the blood brain barrier and central nervous system cell types (microglia, astrocytes, neurons), which can then modulate amyloidosis, tauopathy, and neurodegeneration and contribute to disease ...