gut hormonesgut‐brain axisIslets of LangerhansorexinsLaycock, JohnBoth of Imperial College LondonMeeran, KarimBoth of Imperial College LondonLaycock, JohnBoth of Imperial College LondonMeeran, KarimBoth of Imperial College LondonJohn Wiley & Sons, Ltd...
In this Review, we discuss the complex interplay between the brain, the gut, the microbiota and the kidney in CKD and hypertension and explain our brain–gut–kidney axis hypothesis for the pathogenesis of these diseases. Consideration of the role of the brain–gut–kidney axis in the ...
the lack of effective treatments underscore the urgent need for innovative therapeutic strategies. The brain-gut axis has emerged as a crucial bidirectional pathway connecting the brain and the gastrointestinal
In 2015, the gut microbiota was shown to participate in the biosynthesis of serotonin (5-HT)9, thus, the “gut–brain axis” hypothesis was for the first time demonstrated with clear chemical evidence. However, this study showed that spore-forming bacteria from the mice or human microbiota ...
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases Jian Sheng Loh Wen Qi Mak Kooi Yeong Khaw Signal Transduction and Targeted Therapy (2024) miR-143-3p modulates depressive-like behaviors via Lasp1 in the mouse ventral hippocampus Hui Yu Xiaobing Li Yue ...
There is increasing evidence showing that the dynamic changes in the gut microbiota can alter brain physiology and behavior. Cognition was originally thought to be regulated only by the central nervous system. However, it is now becoming clear that many
This sends out a shockwave that damages the enemies at the front the most, and the ones at the back the least; if the hammer's head falls off, foes in back will take no damage unless the enemies are close enough on the X axis. During Giant Battles, the hammer is split into two ...
brain-gut signaling through humoral, neural, and immunological pathogenic pathways [14]. The central nervous system (CNS) alters the intestinal microenvironment by regulating gut motility and secretion as well as mucosal immunity via the neuronal-glial-epithelial axis and visceral nerves [15,16,17,...
Furthermore, the detected alteration in pipecolic acid levels lead to hypothesize about the early triggering of the gut–brain axis dysregulation and peroxisomal failure. Although the biological purpose of these events is still unknown, the mechanisms involved in the suggested mitochondrial dysfunction, ...
Wilck, N. et al. Salt-responsive gut commensal modulates T H 17 axis and disease. Nature 551, 585 (2017). Article CAS PubMed PubMed Central Google Scholar Ferguson, J. F. et al. High dietary salt–induced DC activation underlies microbial dysbiosis-associated hypertension. JCI Insight http...