The CD14 rs2569190 TT Genotype Is Associated with an Improved 30-Day Survival in Patients with Sepsis: A Prospective Observational Cohort Study. PLoS One 2015; 10: e0127761.Mansur A, Liese B, Steinau M, et al. The CD14 rs2569190 TT Genotype Is Associated with an Improved 30-Day ...
due to pneumonia. The FER rs4957796 TT genotype remained a significant covariate for the 90-day mortality risk in the multivariate analysis (hazard ratio, 4.62; 95% CI, 1.58–13.50; p = 0.0050). In conclusion, FER rs4957796 might act as a prognostic variable for survival in patients ...
A quantity that is proportional to the mean number of viable, fertile progeny produced by a genotype. DEFICIENCY MAPPING A type of genetic mapping that uses chromosomal deletions to 'uncover' recessive alleles that affect a trait. COMPLEMENTATION TESTS The use of genetically defined knockout mutation...
However, in subjects with the MTHFR 677 TT genotype, plasma homocysteine concentrations did not differ among the GNMT C1289T genotypes. Overall, these data suggest that the GNMT 1289 C3T polymorphism influences plasma homocysteine and is responsive to folate intake. J. Nutr. 135: 2780–2785, ...
japonicum (KOSJ group, genotype PKCλ/ιflx/flxCreOX40, n = 5). Each mouse in the WTSJ group and KOSJ group was infected with 15 S. japonicum cercariae on the abdo- men. At 7 weeks post-infection, the mice were anesthe- tized using CO2, and blood was collected ...
We have previously documented that genetic variation at the estrogen receptor α gene locus is associated with gender-specific differences in LDL-C lowering response to atorvastatin (33). While our data suggest sex-specific effects of the NPC1L1 genotype on lipid-lowering response, none of the ...
Dowell RD, Ryan O, Jansen A, Cheung D, Agarwala S, Danford T, Bernstein DA, Rolfe PA, Heisler LE, Chin B, et al: Genotype to phenotype: a complex problem. Science. 2010, 328: 469-10.1126/science.1189015. Article PubMed Central CAS PubMed Google Scholar Boone C, Bussey H, Andrew...
Mendelian randomization is a special type of instrumental variable analysis. Its application in the medical field increases in popularity because of its obvious advantages and the rapid development of genomics. This article aimed to introduce the basic concepts, principles, common methods, and limitations...
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by significant and complex genetic etiology. GWAS studies have identified genetic variants associated with ASD, but the functional impacts of these variants remain unknown. Her
The potential evolutionary success of a genotype, defined as the reproductive success or the proportion of genes that an individual leaves in the gene pool of the next generation in a population. The individuals with the greatest fitness leave the highest number of surviving offspring. ...