Many DSD result in a female or feminine phenotype and are considered in more detail in Vol. 3, Female genital system. Those mentioned here are mostly DSD with a male genotype, gonads, or genitalia. Gynecomastia
Even though MBD4 does bind to methylated chromatin and is expressed in mature pollen (Supplementary Table 3), it does not have a TE-silencing phenotype in pollen. It seems possible that MBD4 plays a repressive role in other specific tissues or functions redundantly with unknown silencing ...
Finally, TBE treatment reduced microglial-mediated tau internalization in a dose-dependent manner (Fig. S5f), showing that TBE induces a phenotype similar to that seen with microglial REV-ERBα KO. To explore which lipid species were altered by TBE treatment in microglia, we performed lipidomic...
• The COL5A1 rs12722-TT genotype had a higher number of contact bone injuries per game, and a higher number of moderate severity rated injuries. Introduction Australian Football (AF) is a unique endurance-based team sport interspersed with many high-intensity efforts across a match [1–4]...
The HT352 maternal line with Tt cytoplasm (Tt), the ana- logue of the HT352 (N), was crossed by common bagging with spikes of male parents—the individual of RIL F6: (N) × Borwo. The seeds were planted on the field in two rows J Appl Genetics (2021) 62:59–71 61 (10 ...
each of the respective cell and/or tissue datasets. Additional file14: Fig. S6 shows the complete list of male reproductive tract-specific human genes for which a previously generated mouse model shows male infertility phenotype, as identified in each of the respective cell and/or tissue datasets...
The coexistence of p.H62L mutation with p.P453S was identified and was associated with a more severe phenotype in two Scandinavian patients compared to NC-21OHD normally associated with p.P453S. Functional assays revealed that the p.H62L mutant protein displayed activity consistent with an NC...
Tug1lncRNA regulates gene expression intrans.aAdult tissue types and mouse embryonic fibroblasts (MEFs) used for RNA sequencing of wild-type (WT) andTug1−/−(KO) mice. For each tissue, the number of biological replicates per genotype and the number of upregulated and downregulated genes ...
If the individual also carries a damaged X chromosome, we assume that this imposes an additional cost that affects reproductive success. To calculate the overall fitness of the genotype, the fitness value associated with carrying the damaged X chromosome is multiplied by the fitness value associated...
The term “genotype” refers to a description of the alleles of a gene contained in an individual or sample. The term “single nucleotide polymorphism” (“SNP”) refers to a site of one nucleotide that varies between alleles. The term “oligonucleotide” is used interchangeable with “primer”...