The genetics of hyperuricaemia and gout. Nat Rev Rheumatol 2012;8:610-21.Anthony M. Reginato, David B. Mount, Irene Yang, Hyon K. Choi. (2012) The genetics of hyperuricaemia and gout. Nature Reviews Rheumatology 8 , 610-621 /
Familial Hypercholesterolaemia is an autosomal, dominant genetic disorder that leads to elevated blood cholesterol and a dramatically increased risk of atherosclerosis. It is perceived as a rare condition. However it affects 1 in 250 of the population globally, making it an important public health co...
However, the association between dietary factors and hype... R.,Villegas,and,... - 《Nutrition Metabolism & Cardiovascular Diseases》 被引量: 121发表: 2012年 Recent insights into the pathogenesis of hyperuricaemia and gout Gout is a common rheumatic disease in humans which is characterized by ...
Recent insights into the pathogenesis of hyperuricaemia and gout. Hum Mol Genet. 2009;18(R2):R177–84. Article CAS PubMed Google Scholar Mokry LE, Ross S, Timpson NJ, Sawcer S, Davey Smith G, Richards JB. Obesity and multiple sclerosis: a Mendelian Randomization Study. PLoS Med. 2016...
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Gout is a common chronic disease with urate crystal deposition in and around the joints results from longstanding hyperuricaemia [1, 2]. The general incidence of gout is 1–4% of the general population [3] and the worldwide incidence of gout is reported to increase gradually due to poor ...
The topic of viral respiratory illness has gained much attention recently due to the emergence of the hypervirulent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for COVID-19. In an effort to identify potential therapeutic targets, Gordon et al. [109] have mapped the...
- 《European Journal of Human Genetics》 被引量: 0发表: 2001年 Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study SummaryBackground Hyperuricaemia, a highly heritable trait, is a key risk factor for gout. We aimed to identify ...
(Lachmann et al.2016). Thus, the genetics of AD are compatible with the endotoxin theory of AD. In addition, as many different AD risk genes affect innate immunity, it is possible that these genes affect the probability of bacterial infection and thereby LPS levels in the body. For ...
factors including hypertension and obesity7,8,9. Gaining insights into the regulation of serum urate levels is important not only to uncover targets to develop urate-lowering and anti-inflammatory therapies to treat gout, but may also provide insights into shared pathways with cardiometabolic risk ...