Linehan WM, Srinivasan R, Schmidt LS (2010) The genetic basis of kidney cancer: a metabolic disease . Nat Rev Urol 7 : 277–285Linehan WM, Srinivasan R, Schmidt LS. The genetic basis of kidney cancer: a metabolic disease . Nat Rev Urol 2010; 7 :277–85...
A quantitative understanding of how pathway context shapes sequence and activity would assist in the interpretation of disease-associated mutations, the design of new enzymes, and directing the laboratory evolution of metabolic pathways. In this work, we examine the residue-level epistatic interactions ...
Alzheimer's disease (AD) is a complex disorder with a clear genetic component. Three genes have been identified as the cause of early onset familial AD (EOAD). The most common form of the disease, late onset Alzheimer's disease (LOAD), is, however, a sporadic one presenting itself in ...
investigate how genetic ancestry influences the expression of genes in the brain, an effort supported by community leaders who raised funding, partnered in shaping research questions and had a central role in the interpretation and communication of the study’s findings. Here, we outline the public...
The genetic defect of GLUT1 or G6PD causes a spectrum of diseases, but the vast majority of persons with G6PD deficiency also may be asymptomatic.69,70 Therefore, clinical-grade G6PD inhibitors may have the potential to improve the PDAC treatment response. Overall, our study provides a new ...
molecular biology- the branch of biology that studies the structure and activity of macromolecules essential to life (and especially with their genetic role) cistron,gene,factor- (genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and fo...
Duration of lactation and incidence of the metabolic syndrome in women of reproductive age according to gestational diabetes mellitus status: a 20-Year prospective study in CARDIA (Coronary Artery Risk Development in Young Adults). Diabetes. 2010;59(2):495-504.PubMedGoogle ScholarCrossref 6. ...
28 The GBD 2016 Study did not stratify health by these categories, and a full discussion of this important topic is beyond the scope of this article. For example, disparities attributed to race may in fact reflect differences in access to high-quality health care or genetic factors.29 The ...
The extraordinary success of mRNA vaccines against coronavirus disease 2019 (COVID-19) has renewed interest in mRNA as a means of delivering therapeutic proteins. Early clinical trials of mRNA therapeutics include studies of paracrine vascular endothelia
The single-celled ciliate Paramecium bursaria is an indispensable model for investigating endosymbiosis between protists and green-algal symbionts. To elucidate the mechanism of this type of endosymbiosis, we combined PacBio and Illumina sequencing to as