The use of automated tools to reconstruct lipid metabolic pathways is not warranted in plants. Here, the authors construct Plant Lipid Module for Arabidopsis rosette using constraint-based modeling, demonstrate its integration in other plant metabolic models, and use it to dissect the genetic architect...
et al. Persistent metabolic youth in the aging female brain. Proc. Natl Acad. Sci. USA 116, 3251–3255 (2019). Article PubMed PubMed Central Google Scholar Lin, J. Divergence measures based on the Shannon entropy. IEEE Trans. Inf. Theory 37, 145–151 (1991). Article Google Scholar ...
Alnylam Pharmaceuticals developed two other RNAi therapeutics that were recently approved for the treatment of acute hepatic porphyria (AHP) and primary hyperoxaluria type 1 (PH1). AHP is an inherited metabolic disorder caused by variants in delta-aminolevulinic acid dehydratase (ALAD)gene...
Group Information: A complete list of the members of the 23andMe Research Team, China Kadoorie Biobank Collaborative Group, and Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium appears in Supplement 8. Disclaimer: The content is solely the responsibility of the authors and...
Besides traditional vascular risk factors like high blood pressure, diabetes, smoking, stress, obesity, and metabolic syndrome, there is a growing list of less traditional and soluble markers such as high LDL or low HDL, CRP, LP (a), homocysteine, LDL particle size, Lp-PLA2, ApoB/ApoA [...
In this paper we review clinical and genetic aspects of testicular germ cell tumours (TGCTs). TGCT is the most common type of malignant disorder in men aged 15-40 years. Its incidence has increased sharply in recent years. Fortunately, survival of patien
Alzheimer's disease (AD) is a complex disorder with a clear genetic component. Three genes have been identified as the cause of early onset familial AD (EOAD). The most common form of the disease, late onset Alzheimer's disease (LOAD), is, however, a sporadic one presenting itself in ...
Diabetes, metabolic abnormalities, and glaucoma. Arch. Ophthalmol. 127, 1354 (2009). Article CAS PubMed Google Scholar Müssig, K. et al. Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion. Diabetes 58, 1715–1720 (2009). Article PubMed Pub...
ConsensusPathDB is a database system that integrates functional interactions, including binary and complex protein–protein, genetic, metabolic, signaling, gene regulatory and drug-target interactions, as well as biochemical pathways32. The genome-wide gene-based association, the gene sets, and the ...
Tay-Sachs disease, hereditary metabolic disorder that causes progressive mental and neurologic deterioration and results in death in early childhood. The disease is inherited as an autosomal recessive trait and occurs most commonly among people of eastern European (Ashkenazic) Jewish origin. In infants ...