Genome-wide association studies (GWAS) have mapped thousands of susceptibility loci associated with immune-mediated diseases. To assess the extent of the genetic sharing across nine immune-mediated diseases we apply genomic structural equation modelling
(4) associated biochemical findings. The growth disorders selected for inclusion are examples and are by no means a comprehensive list of all known genetic diseases that have some effect on growth. Information on each disorder is summarized and, for most of the disorders, more detailed information...
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Carbohydrate-Deficient Glycoprotein Syndrome is a congenital metabolic disorder stemming from impaired glycan binding to other complexes, such as proteins or lipids. The etiology of this syndrome is linked to a mutation in the Phosphomannomutase 2 gene. The Phosphomannomutase gene encodes a phosphoma...
Group Information: A complete list of the members of the 23andMe Research Team, China Kadoorie Biobank Collaborative Group, and Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium appears in Supplement 8. Disclaimer: The content is solely the responsibility of the authors and...
With the increase in cannabis use rates, cannabis use disorder is being reported as one of the most common drug use disorders globally. Cannabis use has several known physical, psychological, and social adverse events, such as altered judgement, poor edu
However, substantial advances in magnetic resonance spectroscopy, diffusion weighted imaging, dynamic contrast enhanced methods and radiochemistry means that cellular and molecular processes such as angiogenesis, apoptosis, signal transduction and metabolic pathways can now be imaged and ...
(25%, 27), incorrect treatment for that disorder (27%, 23), and insufficient specificity to warrant inclusion (19%, 20). Reviewers also examined the age category in which each intervention was suitable (neonate, infant, child), optimal time after diagnosis for initiation (hours, days/weeks,...
Despite a high prevalence of metabolic trait related diseases in Arabian Peninsula, there is a lack of convincingly identified genetic determinants for metabolic traits in this population. Arab populations are underrepresented in global genome-wide association studies. We genotyped 1965 unrelated Arab indiv...
Alzheimer's disease (AD) is a complex disorder with a clear genetic component. Three genes have been identified as the cause of early onset familial AD (EOAD). The most common form of the disease, late onset Alzheimer's disease (LOAD), is, however, a sporadic one presenting itself in ...