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Its main function is telomere restoration but only in a limited group of cells, including cancer cells. Since it is found in a vast majority of cancer cells, it became a natural target for cancer therapy. However, it has much more functions than just altering the metabolism of telomeres鈥攊...
Notably, in comparison to ZH13-2019, we identified 707 novel genes within the gap regions. The results of the Gene Ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis obtained through KOBAS (Knowledgebase for Ontology-based Functional Annotation ...
Telomerase access to and activity at telomeres for telomere maintenance is tightly regulated. In normal conditions, a six-numbered protein complex, called shelterin, is composed of POT1, TPP1, TIN2, TRF1, TRF2, and RAP1 and protects the telomeric DNA ends. As a main component of shelterin,...
Noun1.telomere- either (free) end of a eukaryotic chromosome; "telomeres act as caps to keep the sticky ends of chromosomes from randomly clumping together" chromosome- a threadlike strand of DNA in the cell nucleus that carries the genes in a linear order; "humans have 22 chromosome pairs...
Before and after pancreatic cancer, telomerase is reactivated, and telomeres are maintained at a certain length, which allows pancreatic cancer cells to escape from replicative senescence and make pancreatic cancer continue to develop. Full size image Function and structure of telomere and telomerase In...
Telomeres are specialized structures at the end of chromosomes essential for maintaining genome stability and cell viability. The importance of telomeric proteins for telomere maintenance has increased our interest in the identification of homologues wit
Still more likely is the involvement of the polycomb group gene Bmi-1. Bmi-1 has been shown to play a key role in maintaining indefinite self-renewal of normal stem and cancer stem cells, a function which must necessarily be linked to maintenance of telomeres in stem cells (discussed below...
ribosome biogenesis are significantly enriched (Fig.1gand Supplementary Data5), likely reflecting the B cells immediate response to activation. Between 3 and 10 h, we observed enrichment for metabolic genes (Fig.1hand Supplementary Data5), while, of note, the predicted function of the ...
It is therefore believed that telomeres are part of a mechanism to detect the number of cell replications and DNA damage with the function of preventing uncon- trolled cell proliferation, the main hallmark of cancer (Wright and Shay, 2005; Aubert and Lansdorp, 2008). On the other hand, ...