T cellsNaive T cells have long been regarded as a developmentally synchronized and fairly homogeneous and quiescent cell population, the size of which depends on age, thymic output and prior infections. However,
The full spectrum of human naive T cells. Nat. Rev. Immunol. 18, 363–373 (2018). Article CAS PubMed Google Scholar Sallusto, F., Geginat, J. & Lanzavecchia, A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu. Rev. Immunol. 22, 745...
The opposing ends of an evolutionarily driven spectrum of T cell metabolic states are marked by the differences in metabolic demand and output between quiescent naive or memory cells and effector T cells. Metabolic pathway use early after the re-activation of memory T cells is distinct from that ...
During genomic rearrangement some of the T cells are committed to the γδ lineage14,15, which is not restricted to MHC-I-presented peptides, but rather the γδTCRs recognize both self and foreign stress-ligands16,17,18. γδT cells are the first to emerge in human and mouse embryonic...
Show full outline Cited by (4) Figures (16) Show 10 more figures Tables (1) Table Extras (6) Download all Table S1. Overview of n values, lineage allocation and success rates for embryo experiments, related to Figures 1 and S1 Table S2. Analysis of scRNA-seq dataset for nEnd to ...
The activation of a broad spectrum of T cells was suppressed in the immunosuppressive TME, which eventually facilitated the circumvention of the immune system and the escape of malignant cells, thereby promoting cancer progression and metastasis [17]. The number of CD4+ T cells have been ...
These trials also demonstrated feasibility and safety as well as suggestive signs of potential clinical benefit as standalone therapy or combined with ICBs.14,15,19,20 Dendritic cells (DCs) are the most potent antigen-presenting cell (APC), with the unique ability to prime naive T cells, and...
Full size image Regulatory T cells (Tregs) suppress the activity of effector T cells to maintain immune homeostasis, and their number is increased in the TME. Tregs facilitate immune evasion and are stimulated to expand and differentiate by TGF-β. TGF-β in combination with IL-2 enforces a...
So long as zero personal inconvenience is involved (e.g. lifestyle changes, tax increases etc), most people are relaxed about improving the lives of human and nonhuman animals, and happy to signal their virtue accordingly. This is the Principle of Weak Benevolence - less formally, "no skin ...
With the current invention, we provide new methods of enhancing the T-cell stimulatory capacity of human dendritic cells (DCs) and their use in cancer vaccination. The method comprises the introduction of different molecular adjuvants to human DCs through transfection with at least two mRNA or DNA...