Naive T cells have long been regarded as a developmentally synchronized and fairly homogeneous and quiescent cell population, the size of which depends on age, thymic output and prior infections. However, there is increasing evidence that naive T cells are heterogeneous in phenotype, function, ...
The full spectrum of human naive T cells. Nat. Rev. Immunol. 18, 363–373 (2018). Article CAS PubMed Google Scholar Sallusto, F., Geginat, J. & Lanzavecchia, A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu. Rev. Immunol. 22, 745...
Aneuploidy is a hallmark of human cancer, yet the molecular mechanisms to cope with aneuploidy-induced cellular stresses remain largely unknown. Here, we induce chromosome mis-segregation in non-transformed RPE1-hTERT cells and derive multiple stable clo
In the human body, T cells play a key role in the maintenance of immune tolerance and in the defense against infections and cancer. During T-cell development in the thymus, self-reactive thymocytes are negatively selected by MHC class I- and II-expressing thymic epithelial cells and dendritic ...
of the developmental state and function of human mucosal immune system at birth from that of naive and immature1, 2, 3, 4, 5 to one that is dominated by T cells capable of effector memory function, albeit potentially serving functions distinct from what is required of adult immune cells.6...
Glioma has become the most common brain malignant tumor that affects human health and survival, bringing a heavy burden to patients and their families. Accurate assessment of tumor proliferation of glioma is essential for selecting the optimal treatment strategy. However, the current pathological method...
The activation of a broad spectrum of T cells was suppressed in the immunosuppressive TME, which eventually facilitated the circumvention of the immune system and the escape of malignant cells, thereby promoting cancer progression and metastasis [17]. The number of CD4+ T cells have been ...
Cells and Culture Conditions Myometrial samples were obtained from premenopausal women undergoing hysterectomy (3). The human GIST-T1 cells were previously established from a patient with metastatic imatinib-naive GIST and display an imatinib-sensitive KIT mutation in exon 11 (V560-Y579del) (46)....
In this Review, we introduce the idea that the spectrum of immune cell metabolic states can provide a basis for categorizing human diseases. Specifically, we first summarize the metabolic and interlinked signalling requirements of T cells responding to acute infection. We then discuss how metabolic ...
The cellular landscape of the human intestinal tract is dynamic throughout life, developing in utero and changing in response to functional requirements and environmental exposures. Here, to comprehensively map cell lineages, we use single-cell RNA seque