Neutrophils efficiently cross-prime naive T cells in vivo. Blood. 2007; 110 :2965–2973. [ PubMed ]Beauvillain C. et al. . Neutrophils efficiently cross-prime naive T cells in vivo . Blood 110 , 2965–2973 (2007).Beauvillain C., Delneste Y., Scotet M., Peres A., Gascan H., ...
(APC). Specialized cell that can prime naive T cells through the expression of MHC class I molecules (which are expressed by most cells and can prime CD8+ cytotoxic T cells) as well as MHC class II molecules (which prime CD4+ T helper cells). Vector interference The observation that re-...
Specialized cell that can prime naive T cells through the expression of MHC class I molecules (which are expressed by most cells and can prime CD8+ cytotoxic T cells) as well as MHC class II molecules (which prime CD4+ T helper cells). strategies that target viral, bacterial or parasitic ...
Although pDCs need to be in a certain state of maturation to prime naive T cells, cDCs can stimulate donor T cells even in unirradiated mice. Thus, the capacity of pDCs to prime naive T cells is far less efficient than cDCs in an uninflamed environment. Host pDCs may not be responsible...
Keating, T. Berthoud, L. Andrews, et al. A DNA prime-modified vaccinia virus ankara boost vaccine encoding thrombospondin-related adhesion protein but not circumsporozoite protein partially protects healthy malaria-naive adults against Plasmodium falciparum sporozoite challenge Infect Immun, 74 (2006), ...
Liver Sinusoidal Endothelial Cells Are Insufficient to Activate T Cells Liver sinusoidal endothelial cells (LSEC) have been reported to express MHC class II, CD80, CD86, and CD11c and effectively stimulate naive T cells. Becaus... SC Katz,VG Pillarisetty,JI Bleier,... - 《Journal of Immunolog...
Deple-tion of antibody-bound cells with streptavidin-coated magneticbeads (Dynal) was performed in PBS/0.1% BSA according to themanufacturer’s instructions.Proliferation Assay.To detect OVA cross-priming, differentDC preparations from injected mice were used as stimulators fornaive OT-I cells in a...
This study indicates that dendritic cells (DC) and macrophages (M phi) both serve as APCs that support priming of CD8+ CTL precursors in vivo to exogenous HBsAg particles. After transfer into a syngeneic, naive host, HBsAg particle-pulsed DC, either freshly purified from skin or derived from...
Activation of nave cluster of differentiation (CD)8 cytotoxic T lymphocytes (CTLs) is a tightly regulated process, and specific dendritic cell (DC) subsets are typically required to activate naive CTLs. Potential pathways for antigen presentation leading to CD8 T-cell priming include direct presenta...
Lymphatic endothelial cells (LECs) chemoattract naïve T cells and promote their survival in the lymph nodes, and can cross-present antigens to naïve CD8+ T cells to drive their proliferation despite lacking key costimulatory molecules. However, the functional consequence of LEC priming of CD8...