is initially adopted. This becomes increasingly proinflammatory.bIn the chronic spinal injury scar, monocyte-derived macrophages/microglia adopt a predominantly M1 phenotype. Rather than entering a phase of resolution, responding innate immune cells present DAMPs to circulating adaptive immune cells and path...
If the local inflammatory response to an infection is insufficient to control it, then a systemic acute phase response is induced which may include fever, leukocytosis and altered expression of acute phase proteins [9,48]. This co-ordinated reaction is triggered by both pathogen-associated ...
In the wound healing process, the morphology of keratinocytes at the wound edge temporarily changes to a spindle morphology, which is thought to occur due to an epithelial–mesenchymal transition (EMT). Fibroblast growth factor (FGF) 2, also called basic FGF, has the potential to accelerate woun...
During the diastolic phase, blood flows into the right atrium from the superior and inferior vena cava, which elevates the internal pressure of the right atrium. When the right atrial pressure surpasses the right ventricular pressure, the tricuspid valve passively opens, enabling the blood to move...
Objective To determine the effectiveness and safety of transfusing patients with severe trauma and major bleeding using plasma, platelets, and red blood cells in a 1:1:1 ratio compared with a 1:1:2 ratio. Design, Setting, and Participants Pragmatic, phase 3, multisite, randomized clinical tri...
Plasmin is part of an intricate protease network controlling proteins of initial hemostasis/coagulation, fibrinolytic and complement system. Activation of these protease cascades is required to mount a proper inflammatory response. Although best known for its ability to dissolve clots and cleave fibrin, ...
(FXI) are promising alternatives as deficiencies in these factors protect against thrombosis without causing spontaneous hemorrhage, as revealed by epidemiological and preclinical data. Ixodes ricinus‐contact phase inhibitor (Ir‐CPI), a new anticoagulant candidate with an innovative mechanism of action ...
The coagulation cascade represents a sophisticated and highly choreographed series of molecular events taking place in the blood with important clinical im
ECM and growth factor binding sites in the N-terminus of MAGP-1 The N-terminal portion of MAGP-1 interacts noncovalently with proteins through the anionic acidic and sulfotyrosine residues (Fig. 2). The first protein shown to specifically bind to MAGP-1 was tropoelastin, the elastin precurs...
The impact of clopidogrel on plasma-soluble CD40 ligand levels in systemic lupus erythematosus patients: the CLOPUS phase I/II pilot study. Jt. Bone Spine 88, 105097 (2021). Google Scholar Parker, W. A. E. et al. Aspirin, clopidogrel and prasugrel monotherapy in patients with type 2 ...