is initially adopted. This becomes increasingly proinflammatory.bIn the chronic spinal injury scar, monocyte-derived macrophages/microglia adopt a predominantly M1 phenotype. Rather than entering a phase of resolution, responding innate immune cells present DAMPs to circulating adaptive immune cells and path...
East Asia, and has become a global disease A 2017 retrospective study of the incidence and prevalence of IBD worldwide published in The Lancet2 showed that the incidence in Europe and the United States has reached a plateau while non-Western countries are in the first phase of new case ...
Clinical practice shows that a critical unmet need in the field of medical device‐associated thrombosis prevention is the availability of an anticoagulant therapy without hemorrhagic risk. In the quest for new drugs that are at least as effective as those currently available, while avoiding bleeding ...
This circulatory system is known as the lesser circulatory system with a lower resistance circuit [3]. Such circulation begins at the right ventricle and terminates in the left atrium [3]. At first, the right ventricular blood flows to the lungs via the pulmonary artery [24]. By means of ...
Background Diagnostic errors cause substantial preventable harm, but national estimates vary widely from 40,000 to 4 million annually. This cross-sectional analysis of a large medical malpractice claims database was the first phase of a three-phase proje
Objective To determine the effectiveness and safety of transfusing patients with severe trauma and major bleeding using plasma, platelets, and red blood cells in a 1:1:1 ratio compared with a 1:1:2 ratio. Design, Setting, and Participants Pragmatic, phase 3, multisite, randomized clinical tri...
The functional significance of tyrosine sulfation in MAGP-1 is unclear. ECM and growth factor binding sites in the N-terminus of MAGP-1 The N-terminal portion of MAGP-1 interacts noncovalently with proteins through the anionic acidic and sulfotyrosine residues (Fig. 2). The first protein ...
By forming the key protein component of blood clots, fibrin acts as a structural biomaterial with biophysical properties well suited to its role inhibiting fluid flow and maintaining hemostasis. Based on its clinical importance, fibrin is being investigated as a potentially valuable molecular target in...
In the wound healing process, the morphology of keratinocytes at the wound edge temporarily changes to a spindle morphology, which is thought to occur due to an epithelial–mesenchymal transition (EMT). Fibroblast growth factor (FGF) 2, also called basic FGF, has the potential to accelerate woun...
The principle of the first strategy is simple. Tandem VHHs were expressed in procaryotic or eukaryotic expression systems. The protein bands in lanes 1, 2, and 6 illustrated the intercomparison among the molecular weights (Fig. 4: lane 1, VHH: 17 kDa; lane 2, VHH-VHH: 35 kDa; lane ...