Herein, I discuss the evolutionary biology of viral emergence, set within the analytical framework of fitness landscapes provided by population genetics, and the possible reasons why some viruses may be more likely to emerge than others. Particular emphasis is given to the complex interplay between ...
F. et al. The evolutionary genetics of emerging plant RNA viruses. Mol. Plant-Microbe Interact. 24, 287–293 (2011). 6. Holmes, E. C. The evolutionary genetics of emerging viruses. Annu. Rev. Ecol. Evol. Syst. 40, 353–372 (2009). 7. Domingo, E. Mechanisms of viral emergence. ...
We start by defining cooperation in the evolutionary sense, noting that the evolutionary definition of cooperation differs from how the term is often used in virology. We then define cheating, discuss how both cooperation and cheating can occur in viruses, and show how to test experimentally whethe...
“Why do parasites harm their host?” is a recurrent question in evolutionary biology and ecology, and has several implications for the biomedical sciences, particularly public health and epidemiology. Contrasting the meaning(s) of the concept of “virulence” in molecular pathology and evolutionary e...
Currently, molecular biology, genetics, and genomics are facing a historic opportunity. Since clustered regularly interspaced short palindromic repeats (CRISPR) was discovered in the 1980s, CRISPR and the CRISPR-associated system (Cas) have been rapidly developed into a third generation of gene-editing...
For this reason, the assignment of pattern 3 was maintained for all the samples with this combination of mutations. The distribution of the variants changed over time according to the emergence and expansion of those with the greatest evolutionary advantage. At the end of December 2020, four ...
The origin, emergence and evolutionary genetics of dengue virus Dengue is one of the most important emerging viruses, posing a threat to one-third of the global human population. Herein we show how the comparative analy... EC Holmes,SS Twiddy - 《Infection Genetics & Evolution》 被引量: 802...
Infection, Genetics and Evolution 9 , 1185-1196 /... WY Chi,CC Hon,M Shi,... - 《Infection Genetics & Evolution Journal of Molecular Epidemiology & Evolutionary Genetics in Infectious Diseases》 被引量: 57发表: 2009年 Influenza as a model system for studying the cross–species transfer and...
the evolutionary processes surrounding host jumps. We ascertain overall trends in the directionality of viral host jumps between human and non-human vertebrates and quantify the amount of detectable adaptation associated with putative host jumps. Finally, we examine, for a subset of viruses, signatures...
The application of clustered regularly interspaced short palindromic repeats (CRISPR) for genetic manipulation has revolutionized life science over the past few years. CRISPR was first discovered as an adaptive immune system in bacteria and archaea, and then engineered to generate targeted DNA breaks in...