Ravina E. The Evolution of Drug Discovery: from traditional medicines to modern drugs. John Wiley & Sons Eds, 2011, pag. 75.Ravina, E. The evolution of drug discovery: from traditional medicine to modern drugs. 2011, WILEY-VCH Verlag GmbH & Co. KGaA: Weinheim, Germany....
The Evolution of Drug DiscoveryThomas Klabunde
The growing field of drug discovery and development is facilitating an environment of collaboration between researchers and the pharmaceutical industry. This allows researchers to focus on discovering essential lead compounds for different forms of cancer and other diseases. Globally, research institutes and...
Here, we describe innovations in the key components of such strategies and highlight pioneering examples that indicate the potential of the directed-evolution concept. We also discuss the scientific gaps and challenges that remain to be addressed to realize this potential more broadly in drug ...
influencing the “drugability” of macrocyclic molecules are beginning to be understood, but the worth of this knowledge in enabling drug discovery still remains to be proven. Another aspect of macrocycle drug discovery that is consistent with small molecule efforts is that ...
The first decade of the 21st century was a challenging period for the pharma sector and could prove to be a turning point in the evolution of the industry... KI Kaitin,J.A. DiMasi - 《Clinical Pharmacology & Therapeutics》 被引量: 338发表: 2011年 The evolution of drug development in ...
We conclude that target-based drug discovery is successful and recognize that high-throughput screening and other innovations applied in the past 25 years have only recently started to have a major impact on new approvals. We further suggest viewing phenotypic screening as a logical evolution of ta...
Here, we describe innovations in the key components of such strategies and highlight pioneering examples that indicate the potential of the directed-evolution concept. We also discuss the scientific gaps and challenges that remain to be addressed to realize this potential more broadly in drug ...
The logical conclusion is to use combinatorial genomics together with HTPS to direct plant cellular 'evolution' continuously towards metabolites with specific pharmacologic activity. Mankind would then become the orchestrator of plant secondary metabolism, rather than its passive beneficiary. 展开 关键词:...
Natural products have been a rich source of compounds for drug discovery. However, their use has diminished in the past two decades, in part because of technical barriers to screening natural products in high-throughput assays against molecular targets. Here, we review strategies for natural product...