The discovery of penicillin from a fungus sparked a postwar search for other antibiotics, and for lead compounds that were useful in other areas of medicine. In more recent years, advances in genomics and proteomics identified numerous potential drug targets, which initiated the development of ...
其中,有很多是全新的药物种类。 在与巴斯德齐名的柯赫的实验室里,贝林与柴里北三郎分别发现了白喉杆菌(可引起急性呼吸道疾病,白喉)免疫动物后,动物血清中有一种抗菌物质(即抗体),于是柯赫让两人合作。他们共同发了一篇文章,贝林又单独发表一篇文章,阐明了他们发现的“抗毒素”,开创了免疫学的新时期。同样在柯赫实...
1946年美国止痛与镇静剂研究所(the Institute for the Study of Analgesic and Sedative Drugs)拨款给纽约市卫生局(New York City Department of Health)研究止痛剂的问题。伯纳德·布罗迪(Bernard Brodie)和朱利叶斯·阿克塞尔罗德(Julius Axelrod)被分配研究非阿司匹林类退热剂为何产生高铁血红蛋白症(一种非致命的血液疾...
History of drug discovery: Early evaluation studies and lessons learnt from - Ahmad, Makaya, et al. () Citation Context ...ird of the human population is reported to be latently infected with Mycobacterium tuberculosis, and millions of lives are lost every year [1]. In addition to many ...
新药发现史话(二)(BriefHistoryOfDrugDiscovery)4、白喉抗毒素与606 19世纪初,化学家已经能够从植物中提取和浓缩有效成分,用于治疗目的。如吗啡和奎宁,到20世纪交接时,科学工作者发明了大量的药物,包括合成维生素,磺胺类药物,抗生素,激素(甲状腺素,催产素可的松类药物等),抗精神病药物,抗组胺药物,新的疫苗等。其中,...
Drugs: From Discovery to Approval APPENDIX 1 HISTORY OF DRUG DISCOVERY AND DEVELOPMENT. A1.1 Early History of Medicine.doi:10.5860/choice.41-6569R. NgNg, R. "Drugs: from discovery to approval" Wiley-Liss 2004, 3.Ng, 2004. Drugs - From Discovery to Approval. ... R Ng 被引量: 31发表...
《极简新药发现史》一书,由清华大学出版社编辑出版,其中包含近150余个(种)新药。博客上发表的,只有其中的一半左右,全书340页,正文计324页。目录如下文: 目录 序言 第1章近代新药发现:从尝百草式的经验阶段到近代科学兴起 001 从人痘到牛痘(近代免疫学的发轫):天花疫苗的发现 003 ...
Written by a leading authority with an excellent reputation and ability for writing a good narrative, Drug Discovery: A History is a far cry from simply a list of chemical structures.This lively new text considers the origins, development and history of medicines that generate high media interest...
Written by a leading authority with an excellent reputation and ability for writing a good narrative, Drug Discovery: A History is a far cry from simply a list of chemical structures.This lively new text considers the origins, development and history of medicines that generate high media interest...
To implement this new drug discovery strategy, however, we still have to cope with some challenges, such as the explosive increase of drug combination quantities, the unpredictable pharmacokinetic properties of multiple components and the potential risks of drug–drug interactions. In spite of the rap...