The fact that the renal system has a high resting metabolic rate is well-known, which leads to an abundance of mitochondria. High energy produced by mitochondria must meet the high energy requirements of the kidney for glomerular filtration, urine reabsorption and formation (Bhargava, and Schnellma...
Collectively, our work provides a comprehensive resource for decoding the aging process of microglia, shedding light on how microglia maintain brain functions.Similar content being viewed by others Cellular senescence in white matter microglia is induced during ageing in mice and exacerbates the ...
which is the precursor of omega 6 FAs, and ALA, which is the precursor of omega 3 FAs, are converted to other PUFAs through the addition of double bonds and acyl chains by the enzymes desaturase
Glyceraldehyde-3-phosphate dehydrogenase, the key enzyme responsible for the sixth step of glycolysis, is widely present in various biological cells [1]. The enzyme is encoded by theGAPDHgene and has important functions in cells [2,3]. In plants, GAPDH is often divided into phosphorylated and ...
When there is an enhancement in the glycolysis rate, the conversion of pyruvate to lactate occurs at an increased speed. Thus, if the rate increases,...Become a member and unlock all Study Answers Try it risk-free for 30 days Try it risk-free Ask a question Our experts can ans...
Defective silencing of retrotransposable elements has been linked to inflammageing, cancer and autoimmune diseases. However, the underlying mechanisms are only partially understood. Here we implicate the histone H3.3 chaperone Daxx, a retrotransposable element repressor inactivated in myeloid leukaemia and ...
Colorectal cancer (CRC) is one of the most commonly diagnosed cancers, posing a serious public health challenge that necessitates the development of new therapeutics, therapies, and prevention methods. Among the various therapeutic approaches, interventi
This requires reprogramming of energy metabolism which is considered one of the hallmarks of cancer [1]. Moreover, alteration in energy metabolism leads to nutrition deficiency and metabolic waste accumulation, influencing the biological behavior of nearby non-tumor cells [2]. During the glycolysis ...
By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection. See our privacy policy for more information on the use of your perso...
Clonal expansion of T cells in response to antigen recognition requires dynamic changes in their metabolism [38,39]. As macrophages develop into a more pro-inflammatory phenotype, there is a shift towards enhanced glucose uptake and aerobic glycolysis, whereas anti-inflammatory M2 macrophages have ...