of patients with a fracture experience unsatisfactory healing outcomes.#Emerging evidence highlights the patients' immune competence as a decisive factor in the healing process; various components of the immune system have beneficial or detrimental effects.#Mechanical conditions promote bone regeneration, ...
The decisive early phase of bone regeneration 2023, Nature Reviews Rheumatology Recent advances on small molecules in osteogenic differentiation of stem cells and the underlying signaling pathways 2022, Stem Cell Research and Therapy 3D printing of inorganic-biopolymer composites for bone regeneration 2022...
et al. The decisive early phase of bone regeneration. Nat. Rev. Rheumatol. 19, 78–95 (2023). Article PubMed Google Scholar Schlundt, C. et al. Clinical and research approaches to treat non-union fracture. Curr. Osteoporos. Rep. 16, 155–168 (2018). Article PubMed Google Scholar ...
which poses threats to overall health. Studies have demonstrated a significant association between aging and the dysfunction of neutrophils, critical cells in the early stages of periodontitis, and their crosstalk
building of many fabulous architectural structures, usually ecclesiastic. The wordgobbanactually means ‘blacksmith’, and the euhemerist Irish christians created a number of saints out of the character, known as ‘St Gobban’ or ‘Gobbanus’. As early christian churches were made of wood and...
Drug delivery systems (DDS) have recently emerged as a promising approach for the unique advantages of drug protection and targeted delivery. However, the access of nanoparticles/drugs to the central nervous system (CNS) remains a challenge mainly due to the obstruction from brain barriers. Immune...
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Active AURKA is also present in proximity of cilia during the G0/G1 phase, where it favors the resorption of primary cilium, thereby triggering cell cycle entry [18]. The primary cilium, present in almost all types of vertebrate cells, is a microtubule-containing, hair-like organelle at the...
(latency-associated protein) are internalized by exosomes by binding to exosomal heparan sulfate glycoproteins. Once in the acidic environment of early endosomes, TGF-β dissociates from exosomes and gets activated [78,79]. Cellular deposition of LAP-TGF-β1 is promoted by fibronectins and ...
Osteoarthritis (OA), known as one of the most common types of aseptic inflammation of the musculoskeletal system, is characterized by chronic pain and whole-joint lesions. With cellular and molecular changes including senescence, inflammatory alterations