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The regeneration of bone in a bone deficient site is a time-sensitive process; as such, if bone formation by osteoblasts does not occur in register withsoft callusremodeling, the outcome will be fibrogenesis rather than osteogenesis. Moreover, mechano-transductive signals matched to bone will not...
Man-made scaffolds are indispensable today, in fact autografts are seldom available, and alternative materials lead to poor integration with the host bone owing to the absence of periosteum that contains osteoprogenitor cells and is crucial for growth and remodeling of bone tissue. The pore sizes ...
Bone tissues are one of the most complex tissues in the body that regenerate and repair themselves spontaneously under the right physiological conditions. Within the limitations of treating bone defects, mimicking tissue engineering through the recruitment of scaffolds, cell sources and growth factors, ...
Bone fracture regeneration is a multipart, arranged, reformative procedure that contains a vital numeral of progenitor cells along with inflammatory, endothelial and hematopoietic cells. The bone restorative procedure has three intersecting phases: inflammation, bone production and bone remodeling (Schindele...
Bone regenerates via dedifferentiation of osteoblasts in the zebrafish fin. Dev. Cell 20, 713–724 (2011). Article CAS PubMed Google Scholar Gomez-Salinero, J. M. & Rafii, S. Endothelial cell adaptation in regeneration. Science 362, 1116–1117 (2018). Article CAS PubMed Google Scholar ...
Applications of Bioactive Ions in Bone Regeneration Si Han LIN1,2,3, Wen Jie ZHANG1,2,3, Xin Quan JIANG1,2,3 The repair of large bone defects remains a huge challenge for bone regenerative medicine. To meet this challenge, a number of bone substitutes have been developed over recent ...
Bone is one of the most sophisticated and dynamic tissues in the human body, and is characterized by its remarkable potential for regeneration. In most cases, bone has the capacity to be restored to its original form with homeostatic functionality after
There are several overlapping processes involved in tissue healing, includinghemostasis, inflammation, proliferative phase that potentiates repair and remodeling phase. Adult stem/progenitor cells are important in this process. Their contribution in maintaining normal tissuehomeostasisdoes not instantly replicate...
Pathologically, bone remodeling process has been impaired. A clear understanding of the principles underlying bone loss and repair is essential for the treatment of traumatic injuries (fractures and non-unions), patients with bone infection, osteonecrosis, arthritis, osteoporosis, spinal fusion, wear ...