The combination of alleles or genetic markers found on a single chromosome of a given individual. SITE FREQUENCY SPECTRUM The fraction of polymorphic sites at which a minor or derived allele is present in one copy, two copies and so on. ...
caspases: caspase-3 and caspase-7. Ninety-two proteins were found to be cleaved at one or a few sites (discrete cleavage) in low stress conditions compared to four hundred and fifty-three in apoptotic cells. Many of the cleaved proteins in stressed cells were also found to be cleaved in ...
Publication » Class I alleles detected in the DNA extract exchange, a component of the international cell exchange, 1997–2004.doi:10.1016/j.humimm.2004.07.191Marie LauMin S. ParkJ. Michael CeckaElaine F. ReedElsevier Inc.Human Immunology...
The interpretation of these results, however, will be complex and will most likely require the combination of disciplines as integrative genomics and systems biology. Although difficult, this approach will ultimately allow a more profound understanding of the molecular pathways underlying AD and AD risk...
Exquisite regulation of telomere length is essential for the preservation of the lifetime function and self-renewal of stem cells. However, multiple oncogenic pathways converge on induction of telomere attrition or telomerase overexpression and these events can by themselves trigger malignant transformation...
In the presence of horizontal gene transfer (HGT), the concepts of lineage and genealogy in the microbial world become more ambiguous because chimeric genomes trace their ancestry from a myriad of sources, both living and extinct. We present the evolutio
(mainlyM. m. domesticus), or the presence of artificial selection during mouse domestication, or a combination of all factors. The clustering of classical inbred strains with the wildM. m. domesticusis consistent with the view that the classical inbred mice predominately originate from this ...
We manually characterised transposable elements (TEs) in the genome following a protocol25for TE classification that characterises TEs through a combination of homology-based prediction and manual inspection to find structural motifs and define sequence boundaries. To this end, we created a species-speci...
the best performing model has used a combination of single nucleotide polymorphisms (SNPs) as well as a large number of epidemiological parameters and has achieved a Receiver Operating Characteristic (ROC) Area Under the Curve (AUC) of 0.66 in an internal validation set2. Recent data show that ...
genome was validated using a combination of primers and Sanger sequencing of a BAC clone library generated from genomic DNA (Table 1). Both phylogenetic and synteny analyses support the hypothesis that the ema family underwent expansion prior to the speciation event that led to separation of the ...