Hair cell loss in the cochlea is caused by ototoxic drugs, aging, and environmental stresses and could potentially lead to devastating pathophysiological effects. In adult mammals, hair cell loss is irreversible and may result in hearing and balance deficits. In contrast, nonmammalian vertebrates, ...
Measurements of acoustic input impedance of the cochlea in cats Although the middle ear is often called an impedance matching device, published measurements of the load impedance presented by the cochlea are not extensi... TJ Lynch,V Nedzelnitsky,WT Peake - 《Acoustical Society of America Journal...
The cochlea is innervated by type I and type II afferent neurons. Type I afferents are myelinated, larger diameter neurons that send a single dendrite to contact a single inner hair cell, whereas unmyelinated type II afferents are fewer in number and rec
Cells of the immune system are present in the adult cochlea and respond to damage caused by noise exposure. However, the types of immune cells involved and their locations within the cochlea are unclear. We used flow cytometry and immunostaining to revea
The fine frequency discrimination required for this task is due largely to the mechanical properties of the cochlea, as indicated indirectly by the presence of large otoacoustic emissions at 61 kHz. A laser diode interferometer was used to measure basilar membrane displacements in the basal turn of...
This antenna sends the stimulation information [End Page 215] to an implanted receiver that decodes the information and sends stimulation pulses to electrodes placed in the inner ear, in the snail-shaped organ named cochlea. The first CIs were built and tested in humans by a French team in ...
GJA1 and other connexins are expressed in the cochlea (Rabionet et al. 2000), and mutations in other connexin proteins (connexin 32, 26, 31, and 30) have been associated with both autosomal dominant and autosomal recessive nonsyndromic hearing impairment, usually sensorineural. The type of ...
the cochlea is supposed to affect neural impulse transmission along the peripheral auditory pathway, and to promote thalamocortical dysrhythmia (Llinas et al.1999; Meyer et al.2014). More specifically, as a consequence of deafferentiation following hair cell loss in the cochlea, the auditory ...
It is unclear whether the cochlea has unique sensitivity to cisplatin or is exposed to higher levels of the drug. Here we use inductively coupled plasma mass spectrometry (ICP-MS) to examine cisplatin pharmacokinetics in the cochleae of mice and humans. In most organs cisplatin is detected ...
Auditory stimulation is detected by the cochlea hair cell and transmitted from the cochlear nucleus via the midbrain to the auditory area of the cerebral cortex. The IC is the auditory nucleus in the midbrain, and all ascending auditory information transmits through the IC to the thalamus. In...