Systemic messenger RNA therapy as a treatment for methylmalonic acidemia. Cell Rep. 21, 3548–3558 (2017). Article CAS PubMed Google Scholar Jiang, L. et al. Dual mRNA therapy restores metabolic function in long-term studies in mice with propionic acidemia. Nat. Commun. 11, 5339 (2020)....
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Proper differentiation of corneal epithelial cells (CECs) from limbal stem/progenitor cells (LSCs) is required for maintenance of ocular homeostasis and clear vision. Here, using a single-cell transcriptomic atlas, we delineate the comprehensive and refi
Finally, we review new data on the transcriptional program and function of rare pancreatic cell types and their implication in diabetes. Major conclusion Novel, single-cell technologies offer high molecular resolution of cellular heterogeneity within the pancreas and provide information on processes and ...
Taken together, the data from both gain-of-function and loss-of-function experiments support the role of adipose-derived FGF21-CCL11 axis as a physiological driver for type 2 immune activation and beiging of scWAT. In primary adipocytes, we found that FGF21 stimulates CCL11 production through...
(HOMA-IR) was calculated as follows: HOMA-IR = fasting insulin (mIU/L) × FBG (mmol/L)/22.5. The levels of FFA, TC, TG, AST and ALT in the liver tissues and serum were detected using FFA, TC, TG, AST and ALT kits (Nanjing Jiancheng Bioengineering Institute, Nanjing, China)...
et al. Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer. Cancer Cell 24, 213–228 (2013). Article CAS PubMed PubMed Central Google Scholar Adam, J., Yang, M., Soga, T. & Pollard, P. J. Rare insights ...
p pBackground/p pSystemic bacterial infections are highly regulated and complex processes that are orchestrated by numerous virulence factors. Genes that a... H Yoon,C Ansong,JE Mcdermott,... - 《Bmc Systems Biology》 被引量: 54发表: 2011年 An energy systems approach to Parkinson's disease...
J. Structure and function of the blood–brain barrier. Neurobiol. Dis. 37, 13–25 (2010). CAS Google Scholar Vanlandewijck, M. et al. A molecular atlas of cell types and zonation in the brain vasculature. Nature 554, 475–480 (2018). CAS Google Scholar Pardridge, W. M. Drug ...
The innate immune response is the first line of defence against invading pathogens and is regulated by complex signalling and transcriptional networks. Systems biology approaches promise to shed new light on the regulation of innate immunity through the