COSMIC is currently the most comprehensive global resource for information on somatic mutations in human cancer, combining curation of the scientific literature with tumor resequencing data from the Cancer Genome Project at the Sanger Institute, U.K. Almost 4800 genes and 250000 tumors have been ...
COSMIC;cancer;somatic;mutation;database INTRODUCTION TheCatalogueofSomaticMutationsinCancer(COSMIC)iscurrentlythemost comprehensiveglobalresourceaccessingtheworldliteratureonsomaticmutationsin humancancer.Thesystemisdesignedtopreserveandimprovetheusefulnessofpublished ...
The Catalogue of Somatic Mutations in Cancer (COSMIC) Cancer Gene Census (CGC) is an expert-curated description of the genes driving human cancer that is used as a standard in cancer genetics across basic research, medical reporting and pharmaceutical development. After a major expansion and comple...
COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer COSMIC (http://www.sanger.ac.uk/cosmic) curates comprehensive information on somatic mutations in human cancer. Release v48 (July 2010) describes over 136,... SA Forbes,B Nidhi,B Sally,... - 《Nucleic ...
In lung adenocarcinoma, mutations in 22 out of 40 common cancer genes were under significant subclonal selection, including classical tumour initiators such as TP53 and KRAS. We defined evolutionary dependencies between drivers, mutational processes and whole genome doubling (WGD) events. Despite ...
Since the discovery in 1982 of the link between HRAS gene mutations and bladder cancer, about 100,000 abnormal genes have been identified in cancer patients. As a result, much has been learned about the development of cancer, but with so many distinct ca
l The catalogue of somatic mutations in a cancer genome n 同生殖系突变一样,体细胞突变以包括SNPs,InDels,rearrangement,copy number variations;可以插入外来病毒的DNA片段。表观遗传改变也可以改变染色质结果和基因表达。 n 线粒体基因组的改变也是癌症的发生的一个原因 u Chatterjee, A., Mambo, E. & Sidr...
COSMIC, the Catalogue Of Somatic Mutations In Cancer (http://cancer.sanger.ac.uk) is the world's largest and most comprehensive resource for exploring the impact of somatic mutations in human cancer. Our latest release (v70; Aug 2014) describes 2 002 811 coding point mutations in over one ...
Cancer dependency maps have accelerated the discovery of tumor vulnerabilities that can be exploited as drug targets when translatable to patients. The Cancer Genome Atlas (TCGA) is a compendium of ‘maps’ detailing the genetic, epigenetic and molecular
Embodiments are related to the accurate detection of somatic mutations in the plasma (or other samples containing cell-free DNA) of cancer patients and for subjects being screened for cancer. The detection of these molecular markers would be useful for the screening, detection, monitoring, management...