BloodBrain BarrierIn autoimmune neurologic disorders, the blood-brain barrier (BBB) plays a central role in immunopathogenesis, since this vascular interface is an entry path for cells and effector molecules of the peripheral immune system to reach the target organ, the central nervous system (CNS)...
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However, the presence of BBB complicates the pharmacotherapy for CNS disorders as the most chemical drugs and biopharmaceuticals have been impeded to enter the...
NeuroRx: The Journal of the American Society for Experimental NeuroTherapeutics The Blood-Brain Barrier: Bottleneck in Brain Drug Development William M. Pardridge Department of Medicine, UCLA, Los Angeles, California 90024 Summary: The blood-brain barrier (BBB) is formed by the brain capillary ...
每个人心中都有一个保镖: 血脑屏障是血管和大脑其他部分之间的一层细胞,它将毒素、病原体和其他可能破坏大脑宝贵灰质的不良物质拒之门外。 当保镖失去警觉,一个粗暴的元素进入时,各种情况都会出现。侵入屏障的癌细胞可以发展成肿瘤,而当太多的白细胞滑过屏障,导致对脑神经保护层的自身免疫攻击,阻碍它们与身体其他...
This timely and compact monograph addresses how to determine drug permeability across the blood-brain barrier more effectively. Focusing on the physiological mechanisms that influence the passage of agents into the brain, the book covers the latest research on the blood-brain barrier, the current prob...
The blood–brain barrier (BBB) protects the central nervous system (CNS) from unregulated exposure to the blood and its contents. The BBB also controls the blood-to-brain and brain-to-blood permeation of many substances, resulting in nourishment of the CNS, its homeostatic regulation and communi...
声音简介 The blood-brain barrier does a good job of keeping toxins out. But this tightly-packed layer of cells which separates the brain from its blood vessels is a hindrance if you want to deliver drugs into the brain. 血脑屏障可以很好地防止毒素侵入。但是,如果你想将药物输送到大脑中,这种...
The blood–brain barrier and blood– tumour barrier in brain tumours and metastases Review. Nat Rev Cancer. 2020 Jan;20(1):26-41. doi: 10.1038/s41568-019-0205-x. 翻译为主,算作自己的功课记录,如果各位知友有相关见解,求慷慨分享。 脑肿瘤及脑转移瘤中的血脑屏障和血瘤屏障...
aThe blood-brain barrier, which prevents bacteria and other foreign bodies from passing from the blood into the fluid surrounding the brain, developed more slowly in some children, Dr Liang wrote in the journal Psychiatry Research, and these individuals' brains might be more susceptible to inflammat...
What is the Blood Brain Barrier? The blood brain barrier is responsible for controlling the movement of ions, molecules and cells between the blood and the delicate neural tissue of the brain, playing a key role in maintaining the homeostasis of the central nervous system. The blood brain barri...