Blood-brain barrierTight junctionsThe blood-brain barrier (BBB) is a restriction of the rate of exchange of certain solutes between blood plasma and brain extracellular fluid. The anatomical basis of this restriction is the absence, in the brain capillary endothelial cell, of the open intercellular...
The blood–brain barrier is a dynamic structure, collectively referred to as the neurovascular unit. It is responsible for the exchange of blood, oxygen, ions, and other molecules between the peripheral circulation and the brain compartment. It is the main entrance to the central nervous system a...
While placental function is fundamental to normal fetal development, the blood-brain barrier provides a second checkpoint critical to protecting the fetal brain and ensuring healthy brain development. The placenta is considered the key barrier between the mother and fetus, regulating delivery of essential...
The blood-brain barrierGrégoire, N
Cornell University researchers may have solved a 100-year puzzle: How to safely open and close the blood-brain barrier so that therapies to treat Alzheimer's disease, multiple sclerosis and cancers of the central nervous system might effectively be delivered. (Journal of Neuroscience, Sept. 14, ...
作者: BB Barrier 摘要: A barrier exists that prevents some substances from reaching the brain from the blood. In this respect the brain is strikingly different from other tissues, which are far more penetrable. In this brief monograph Bakay discusses his investigations of this barrier. In the ...
The blood–brain barrier (BBB) is a selectively permeable membrane that separates the bloodstream from the brain. While useful for protecting neural tissue from harmful substances, brain-related diseases are difficult to treat due to this barrier, as it also limits the efficacy of drug delivery. ...
The blood-brain barrier does a good job of keeping toxins out. But this tightly-packed layer of cells which separates the brain from its blood vessels is a hindrance if you want to deliver drugs into the brain. 血脑屏障可以很好地防止毒素侵入。但是,如果你想将药物输送到大脑中,这种将大脑与其...
Though successes have been achieved through the use of these methods, each has limitations that warrant a more universal delivery system involving the intravenous pathway. Two main barriers to intravenous delivery are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier. This ...
The tight junctions of brain endothelial cells prevent the influx of hydrophilic molecules but do not prevent the entry of toxic substances that are lipophilic. Neurotoxins may also enter the brain if their physiological properties enable them to use any of the carrier mechanisms present in the ...