Rubin I, Yarden Y, The basic biology of HER2. Ann Oncol 2001,12:S3-S8.Rubin I, Yarden Y. The basic biology of HER2. Ann Oncol 2001;12(Suppl. 1):S3-8.Rubin I1, Yarden Y (2001) The basic biology of HER2. Ann Oncol 12 Suppl 1: S3-8....
The LAP family: a phylogenetic point of view. Trends Genet. 2002;18:494–7. CAS PubMed Google Scholar Rubin I, Yarden Y. The basic biology of HER2. Ann Oncol. 2001;12:S3–8. PubMed Google Scholar Huang YZ, Wang Q, Xiong WC, Mei L. Erbin is a protein concentrated at ...
Here, we focus on the pertinent genetic and functional data that support the relevance of members of the Ptp family to human cancer. PTP inhibitors are currently being developed. However, a better understanding of the basic biology of PTPs in human tumour development will be required to improve...
3. Mechanism of HER3-mediated cancer progression Accumulating evidence emphasizes the critical role of HER2/HER3 heterodimer-mediated PI-3K/Akt signaling in cancer development39, 52. Basic research on the underlying mechanisms indicates that HER2 contributes to breast carcinogenesis potentially via two ...
Exquisite regulation of telomere length is essential for the preservation of the lifetime function and self-renewal of stem cells. However, multiple oncogenic pathways converge on induction of telomere attrition or telomerase overexpression and these events can by themselves trigger malignant transformation...
Cell viability was measured as a proportion of healthy (Annexin-negative, PI-negative) cells. Human and mouse datasets The expression levels of ID2 and ALDH3A1 and their relation to the receptor status of ER, progesterone receptor (PR), and HER2 were assessed for breast cancer samples in ...
Affibodies, the backbone of which is based one of the IgG-binding domains of staphylococcal protein-A have been randomized to create libraries selected on such cancer epitopes as HER2 and TNF-alpha to create agents potentially useful for imaging and therapy targeting applications [136], [137]. ...
subtypes of breast cancer and have established AR expression were interrogated: ER+ luminal (ZR-75-1, T-47D) and two subtypes of ER- disease including molecular apocrine/HER2 + (MDA- MB-453) and triple negative (i.e., lacking ER, PR and HER2 expression; MFM-223) [22–24]....
(HER2). The results demonstrated that aCD3-aHER2 SMART-Exos exhibited enhanced binding affinity towards both CD3+ and HER2+ cell lines in vitro, mediating the interaction between T cells and HER2+ tumor cells, thereby activating cytotoxic T cells to target HER2-expressing cancer cells effectively...
From the initial discovery of the diverse cell surface receptors on NK cells to the characterization of regulatory events that control their function, our understanding of the basic biology of NK cells has improved dramatically in the past three decades. This advanced knowledge has revealed increased...