Prokaryotes were long thought to be incapable of expressing circadian (daily) rhythms. Research on nitrogen-fixing cyanobacteria in the 1980s squashed that dogma and showed that these bacteria could fulfill the criteria for circadian rhythmicity. Development of a luminescence reporter strain of ...
cardiovascular control, and glucose metabolism. Circadian clock disruptions, or losses of rhythmicity, have been implicated in the development of several diseases, premature ageing, and are regarded as health risks. Redox reactions involving reactive...
In addition, we have summarized what little is known regarding the physiological function of ovarian clocks. We propose a revised paradigm in which circadian clocks at each level of the HPG axis contribute to the timing of reproductive events, with specific emphasis on the possible role of the ...
Clocks and the black box: circadian influences on gonadotropin-releasing hormone secretion. Although the mechanisms underlying hypothalamic surge secretion of gonadotropin-releasing hormone (GnRH) in rodent models have remained enduring mysteries ... PE Chappell - 《Journal of Neuroendocrinology》 被引量:...
Dartmouth Medical School geneticists say they have made new inroads into understanding the regulatory circuitry of the biological clock that synchronizes the ebb and flow of daily activities, according to two studies published May 15. Research on the rel
Circadian effects on performance and effort in collegiate swimmers. J. Circadian Rhythm. 2018, 16, 1–9. [Google Scholar] [CrossRef] [PubMed] Facer-Childs, E.; Brandstaetter, R. The impact of circadian phenotype and time since awakening on diurnal performance in athletes. Curr. Biol. ...
For example, it has been demonstrated that loss of central circadian rhythms accelerates amyloid plaque accumulation, while loss of peripheral Bmal1 in the brain parenchyma increases the expression of ApoE and promotes fibrillar plaque deposition [28]. However, the findings on the association between ...
Plants contain several tissue-specific decentralized but communicating ‘clocks’. These control developmental outputs in response to environmental change: the vasculature clock for photoperiodic control of flowering, and the epidermis clock for temperat
Many vital processes in the eye are under circadian regulation, and circadian dysfunction has emerged as a potential driver of eye aging. Dietary restriction is one of the most robust lifespan-extending therapies and amplifies circadian rhythms with age.
Recent developments, for example, on how waste clearance in the brain could be modulated by the circadian clock, will also be discussed. This synthesis provides insights into the impact of metabolism not only on the circadian clock, but also on sleep and how this connection may exacerbate ...