Cancer appears as a result of mutation of normal tissue cells. In this paper, we consider the initial stage of the cancer appearance and development. In particular, we study the conditions that are necessary for an initial fixation of the mutant cells in a patient tissue and their further ...
Recent evidences in stem cell biology suggest that tumors contain a hierarchy of heterogeneous cell population in which cancer stem cells (CSCs) exist in the top and confer the maintenance ability of tumor formation on transformed cells. In this study, to elucidate the relationship between the expr...
And it's not the decrease in population but the appearance of more flexible attitudes about how lives can be lived that has helped ohitorisama to boom. “It’s only 10 years ago they said ‘lunch in a toilet’,” says Matsushita. “But, after 10 years, we have so many services for...
The pattern on the trampoline represents both fresh and destroyed cancer cells of different types, and other antigens, which are communicated to the brain of the user as he bounces. The trampoline is used as a pacemaker, stimulating the desire centre in the brain which produces the indigenous ...
Senescent cells in cancer tissue, including senescent fibroblasts and macrophages, have been reported to increase the malignant potency of cancer cells by secreting senescence-associated secretory phenotype (SASP). Otherwise, Senescence of tumor cells ha
Most patients with prostate cancer inevitably progress to castration-resistant prostate cancer (CRPC), at which stage chemotherapeutics like docetaxel become the first-line treatment. However, chemotherapy resistance typically develops after an initial p
(right side) is a physiological response to drug stress involving pathways that buffer the stress, such that some cells are able to grow, albeit slowly, in the presence of drug concentrations that are inhibitory to other cells in the population. This involves physiological shifts in: the cell ...
This bicuspid valve is also known as the mitral valve because of its similarity to the miter of a bishop. The cusps of both of these valves are triangular in appearance and are linked to the edges of the fibrous or dense connective tissue surrounding the atrioventricular openings. 4.4.2 ...
Molecular docking is a computational technique that predicts the binding affinity of ligands to receptor proteins. Although it has potential uses in nutraceutical research, it has developed into a formidable tool for drug development. Bioactive substance
In addition, Tisp40 played critical roles in the survival of various cancer cells and closely correlated with the prognosis of these patients21, 22. However, the role and molecular basis of Tisp40 in cardiac I/R injury remains elusive. Here, we show that Tisp40 expression, cleavage and ...