any of the basic elements of heredity, passed from parents to their offspring.If the children are red-haired, one of their parents must have a gene for red hair.gen genetic(dʒəˈnetik)adjective of genes or genetics.a genetic abnormality.genético ...
Lung cancer is the leading cause of cancer-associated mortality worldwide1. Here we analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients with non-small cell lung cancer prospectively enrolled into the TRACERx study. This project aims to decipher lung ...
Interestingly, we discover that TEs affecting known cancer driver genes in cancer have for most part no significant effect on these genes in normal suggesting a tumor-specific effect of these TEs. Additionally, in our study we show that alongside predisposing alleles and somatic mutations, germline...
which is facilitated by eMSCs. These eMSCs were initially discovered as clonogenic stromal cells, constituting 1.25% of stromal cells [6,19]. The discovery of specific surface markers that are enriched in clonogenic endometrial stromal cells led to the identification of their perivascular...
(Van der Merwe et al.1999). Our results are a strong indication that future GRD studies should include artificial inoculation to enhance disease pressure and its uniformity across trials. Lack of sufficient disease pressure would result in poor detection of causal alleles, especially those with ...
Genotypes in the two groups were subjected to Infinium Wheat Barley 40K v1.0 BeadChip (https://www.illumina.com/) for SNP polymorphic alleles between the two groups. Particularly, SNP clustering and genotype calling were performed using GenomeStudio 2.0 software (Illumina). SNPs with a call ...
Horizontal Gene Transfer (HGT) is beneficial to a cell if the acquired gene confers a useful function, but is detrimental if the gene has no function, if it is incompatible with existing genes, or if it is a selfishly replicating mobile element. If the b
Because inferences made on small collection sizes are particularly sensitive to minor alleles as compared to those based on larger sizes, three different MAF cutoffs were investigated. The number of genetically distinct subpopulations (K) was evaluated for each possible K ranging from 1 to 10 along...
Genes that are more highly expressed late in life are significantly more polymorphic for nonsynonymous mutations than are genes expressed early in all four species. Nonsynonymous polymorphism is measured here as the fraction of sites in a gene that segregate for nonsynonymous alleles (pN) relative to...
At a later time point, the sample underwent a whole genome duplication (WGD) event, duplicating all alleles, including the derivative chromosome, in a single event, as evidenced by the mutation time estimates of all copy number gains clustering around a single time point, independently of the ...