aldosterone- a corticosteroid hormone that is secreted by the cortex of the adrenal gland; regulates salt (sodium and potassium) and water balance mineralocorticoid- hormone that is one of the steroids of the adrenal cortex that influences the metabolism of sodium and potassium ...
CONCLUSIONS: These results demonstrate that residual aldosterone has a significant impact on target-organ damage in hypertension, even during chronic administration of an ARB. The addition of an aldosterone antagonist has an advantage in facilitating the cardioprotective effects of ARBs. 展开 ...
Several studies have confirmed a significant clustering between elevated uACR and traditional risk factors for HF, which include insulin resistance [31], inflammatory response [32], and renin-angiotensin- aldosterone system (RAAS) activation [33]. Considering the higher mortality rate in patients with...
Aldosterone synthase inhibition in humans. Aldosterone synthase (CYP11B2) inhibition has emerged as a new option for the treatment of hypertension, heart failure and renal disorders, in addition to ... Michel,Azizi,Laurence,... - Nephrology, dialysis, transplantation : official publication of the ...
In mammals, in addition to aldosterone, the glucocorticoids are also a major ligand of MR; however, almost all the mineralocorticoid functions are mediated by aldosterone-MR signalling5. The high affinity of cortisol for MR means that aldosterone-mediated effects occur in tissues where 11β-hydroxys...
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It is concluded that aldosterone can be synthetized in adrenocortical tissue of chick embryos from day 14 of embryogenesis and therefore it may already play an important role in the regulation of plasma electrolytes. 展开 关键词: adrenocortical tissue corticosteroid biosynthesis chick embryos cytochrome ...
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Addition of NaCl to the mucosal media evoked the same increase in I sc as the addition of aldosterone; both additions increased I sc more than two-fold. Aldosterone reduced lactate production under these conditions while the re-addition of NaCl had no effect on lactate formation. These results...
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