Bollag WB. Regulation of aldosterone synthesis and secretion. Compr Physiol. 2014;4:1017-1055.Bollag WB. Regulation of aldosterone synthesis and secretion. Compr Physiol. 2014;4:1017-1055. doi: 10.1002/cphy.c130037.Bollag WB.Regulation of aldosterone synthesis and secretion[J].Compr Physiol,...
Potassium also stimulates aldosterone synthesis, through a direct action on glomerulosa cells. The secretion of aldosterone is inhibited by natriuretic peptides (ANP and BNP) Cho et al. (2014). Although not used therapeutically, aldosterone has great importance in pathophysiology, where it plays an ...
Aldosterone is a vitally important factor in cardiovascular homeostasis. Tightly regulated control of the biosynthesis and action of this mineralocorticoid hormone are crucial given that its excessive secretion, as seen in primary aldosteronism (PA), can
Angiotensin II (Ang II) is a major regulator of aldosterone synthesis and secretion, and it is known to facilitate reactive oxygen species (ROS) generation in many cell types. Here, we assessed the role of ROS signaling in Ang II-induced aldosterone synthesis by focusing on the regulation of...
Regulation of aldosterone synthesis and secretion. Aldosterone is also thought to directly induce end-organ damage, including in the kidneys and heart. Because of the significance of aldosterone to the physiology and pathophysiology of the cardiovascular system, it is important to ... WB Bollag - ...
aldosterone on β-cell insulin secretion, which is an MR-independent phenomenon (Luther et al., 2011). Recently, some novel and selective ASIs have been discovered that also display rodent potency (Grombein, Hu, Rau, et al., 2015;Papillon, Lou, et al., 2015). These compounds may likely...
Aldosterone secretion of (a,b) normal primary adrenal cells or (c,d) aldosterone-producing adenomas (APAs) in the presence of compound 8 (a,c) or nifedipine (b,d). Dose response curve between 0-100 μM of compound 8 on (a) normal primary adrenal cells (n = 4) and (c...
[21]. Production and secretion of Ang occurs in the liver, but it should be noted that although the liver is the main producing organ, angiotensinogen is additionally produced in the brain, lungs, kidneys, vasculature, and heart [12]. Renin can cleave the N-terminal amino acids of ...
Inhibitory effect of efonidipine on aldosterone synthesis and secretion in human adrenocarcinoma (H295R) cells. Targeting aldosterone synthesis and/or release represents a potentially useful approach to the prevention of cardiovascular disease. Aldosterone production... K Imagawa,S Okayama,M Takaoka,......
LCI699 was administered by oral (rat and monkey) or nasogastric gavage (monkey). Compound doses in the monkey model are quoted as free base equivalents. Experimental protocol for rat models Study protocols for the rat models of Ang-II- and ACTH-stimulated aldosterone synthesis followed a ...