Their activity on the spinal cord is roughly proportional to their local anaesthetic potency. The ratios of the doses which produce the same central activity are amethocaine 3: lignocaine 10: procaine 20.doi:10.1111/j.1476-5381.1960.tb01231.xD. TAVERNER...
Although local anesthetics are considered primarily Na(+) channel blockers, previous studies suggest a common intracellular site of action on different G p... MW Hollmann,KS Wieczorek,B Andreas,... - 《Molecular Pharmacology》 被引量: 235发表: 2001年 Differential effects of bupivacaine on intrace...
The pH dependence of the local anesthetics procaine, tetracaine and dibucaine has been tested on nerve bundles of the crab and on the Ranvier node of single fibers of frog sciatic nerve. Whereas the potency of action on the bundles increases with rising pH, the optimum action at Ranvier nodes...
Snake venoms, especially of Elapidae and Hydrophiidae, have been known for centuries to produce symptoms relevant to nervous systems in the envenomed subject. As described in detail in Chapter 24 and 25, the most characteristic symptom is the paralysis o
1.An agent that causes loss of sensation with or without the loss of consciousness. 2.Something likened to this in effect:For some people watching television is an anesthetic for the mind. [From Greekanaisthētos,without feeling:an-,without; seea-1+aisthētos,perceptible(fromaisthanesthai,to...
Affect of vasoconstrictors Quantitative estimation of anesthetic effect of local anesthetics by analysing somatosensory evoked potentials. Affect of vasoconstrictors... T Ashizawa,S Abe,M Sumitomo,... 被引量: 0发表: 1994年 Method The present invention relates to a method of processing ultrasound ...
9, the effect and speed of barbiturates are related to the drug itself (dissociation constant) and (lipid solubility), while the duration of action is related to the metabolism of (5, 5- double substituent). A molecular phenobarbital (amide structure), the sodium salt solution at room ...
Local anesthetic toxicity is often studied experimentally in acutely prepared, anesthetized laboratory animals. We determined the influence of halothane/O(2) anesthesia on cardiovascular and central nervous system (CNS) toxic responses to six amide-type local anesthetics administered i.v..Behavioral, card...
The ability of a host to survive the invasion of microorganisms and other foreign particles resides mainly with the immune system. It is generally accepted today that the immune response is composed of humoral and cellular arms which act either individua
Dental local anesthetics Background The authors review four techniques for producing block and topical anesthesia that have been advocated as alternatives to conventional methods. The objective of this review is to examine the basis for each method's application... PATRICIA L. BLANTON D.D.S., Ph...