Tabatabai M;Booth AM.Mechanism of action of local anesthetics on synaptic transmission in the rat,1990Tabatabai M,Booth AM.Mechanism of action of local anesthetics on synaptic transmission in the rat. Anesthesia and Analgesia . 1990Mechanism of action of local anesthetics on synaptic transmission in...
Alterations in the nerve cell membrane potential are termed the action potential. Leak currents are present through all the phases of the action potential, including setting of the resting membrane potential and repolarization. Mechanism of action Local anesthetics inhibit depolarization of the nerve ...
muscle, fat 19 The PH of local site Local anesthetics is weak bases (pKa8-9) the fluid pH is higher, rapid onset of action the fluid pH is lower, decrease onset of action (question is why?) 20 Clinical Uses Clinical Uses: --Most frequent use: regional anesthesia --Less common use:...
MechanismofAction Theprimarymechanismofactionoflocalanestheticsisblockadeofvoltagegatedsodiumchannels.Localanestheticsbindtoreceptorsneartheintracellularendofthechannelandblockthechannelinatime-andvoltage-dependentfashion.Classificationoflocalanesthetics Esters酯类1.Procaine(普鲁卡因）2.Chloroprocaine3.Trtracaine丁卡因4....
R. Lieb,Molecular mechanism of general anesthesia. Nature (Lond.)300, 487–493 (1982). Google Scholar P. Bradford and G. V. Marinetti,Trinitrobenzensulphonic acid and fluorodinitrobenzene: Probes to study local anesthetic effect in cell membranes. J. Membr. Biol.61, 193–198 (1981). ...
2 What is the mechanism of action of local anesthesia? What are the implications for differential blockade? Local anesthetics are weak bases that reversibly block sodium channels and impair the propagation of an action potential along a nerve fiber. In general, thinner fibers are more sensitive to...
local anesthetics, the mechanism of action is similar to that of lidocaine. The intensity of action and the onset of action are similar. The maintenance time is longer, the toxicity is lower, and the accumulation is small. Invasive anesthesia f...
pass through the cell membrane to the inside of the membrane. On the other hand, in an acidic environment ( e.g. in inflammatory conditions), their ability to pass through the membrane is poorer and the potency of local anesthesia diminishes. Local anesthetic effect mechanism is inconclusive. ...
the use of local anesthetics by anesthesia providers has gained increasing popularity, traditionally in both obstetric and regional anesthesia. This chapter will focus on the types of local anesthetics, dosing and mechanism of action, indications with clinical pearls, and drug interactions/toxicity profil...
Aspects of the pharmacology of local anaesthetic agents. This article describes the pharmacology of local anaesthetic agents, including the chemistry, mechanism of action, pharmacokinetics, specific local anaesth... LÖFSTRÖM B. - 《British Journal of Anaesthesia》 被引量: 51发表: 1970年 Clinical...