The orientational interaction of a local anesthetic molecule with a biomembrane and the cell liquid was studied in terms of the model of adsorption from solution onto the biomembrane surface for compounds of the trimecaine series. A statistically significant correlation equation was obtained that ...
Anesth Prog. 1978 May-Jun;25(3):87-91. 2. Uskova A, O'Connor JE. Liposomal bupivacaine for regional anesthesia. Curr Opin Anaesthesiol. 2015 Oct;28(5):593-597. 3. Cherobin ACFP, Tavares GT. Safety of local anesthetics. An Bras Dermatol. 2020 Jan-Feb;95(1):82-90....
In numerous clinical studies, PUL has been shown to be minimally invasive, often delivered in the office setting with local anesthesia. Post-operative urinary catheterization is considerably lower than other leading BPH procedures; adverse effects are typically mild to moderate resolving within two to ...
Between February and June 2021, 120 hernia repair surgeries were successfully executed in an ambulatory setting, utilizing solely local anesthesia, without the intervention of an anesthetist. surgical pathology Considering hernia types, a total of 105 inguinal hernias, 6 femoral hernias, and 9 ...
Immediately after entering the room, the patient was given electrocardiogram (ECG) monitoring, oxygen inhalation, central vein and radial artery puncture under local anesthesia, central venous pressure (CVP) and invasive blood pressure monitoring, and fluid resuscitation. Under strict monitoring, small do...
and by reducing the rate of rise of the action potential. Specifically, they block the sodium-channel and decrease chances of depolarization and consequent action potentials. In general, the progression of anesthesia is related to the diameter, myelination and conduction velocity of affected nerve fib...
In particular, local anesthesia (LA) was shown to reduce cancer recurrence in prostate and ovarian tumors [1], and biochemical investigations in vitro revealed the anti-cancer potential of various local anesthetics. For instance, ropivacaine reduced the proliferation of colon cancer cells [3], ...
6 Midazolam is available by oral, rectal, intranasal, intramuscular (IM), and intravenous (IV) routes and has been used in various biomedical applications, including dentistry, cardiac surgery, and endoscopic procedures as pre-anesthetic medication, and as an adjunct to local anesthesia.21 This ...
Lidocaine is an intermediate-acting local anesthetic of the aminoamide type and a sodium channel blocker. In addition to local anesthesia, regional anesthesia, and antiarrhythmic treatment, the clinical application of lidocaine is still very extensive, and its clinical application and brief mechanism are...
2c–e). Further immunohistochemistry experiments performed in C57BL/6J mice with tyrosine hydroxylase (TH) staining and Vgat-IRES-Cre or Vglut2-IRES-Cre mice with local expression of Cre-inducible rAAV-DIO-EGFP showed that the VTA glutamatergic neurons, but not GABAergic or dopaminergic neurons...