14,15,16. In addition, some pH-sensitive bonds like acetal and hydrazone bonds which can be hydrolyzed in the mild acidic environment of the endosomal and lysosomal compartments have been reported15. However, given the fact that different spacers are expected to have different properties that ...
Since the procedure described above can produce duplicate structures, we relied on calculating the nuclear repulsion energy (full results are available in theSupplementary Information). The method was verified using a BEA unit cell (which contains 36 T-atoms) and generating 36 different structures by...
KEYWORDS: Ni catalysis (反应类型), C(sp2)− S (成键类型), Aryl halides (原料), Ketene dithioacetals (原料), Aryl-alkyl thioethers (产物), NiCl2(dme) (催化剂) ABSTRACT: Herein,we present a nickel-catalyzed C−S cross coupling between aryl halides andketene dithioacetals under “bas...
Models can be calibrated to evaluate the preservation status of apples based on variations in ethylene, ethanol, and acetaldehyde levels [145]. The freshness assessment of fish employs RFID tags integrated with sensors for measuring temperature, humidity, and the presence of volatile amine chemicals ...
Yamaguchi A, Hashimoto T, Kakichi Y et al (2015) Recyclable carbon fiber-reinforced plastics (CFRP) containing degradable acetal linkages: synthesis, properties, and chemical recycling. J Polym Sci Part A: Polym Chem 53:1052–1059 Google Scholar Nie W, Liu J, Liu W et al (2015) Decomposi...
6F). We found that the hA4 subtype was more sensitive to drugs such as SCH772984, trametinib, selumetinib, PD0325901, ulixertinib, mitoxantrone, and foretinib and resistant to drugs such as sapitinib, afatinib, lapatinib, OSI-027, ULK1_4989, acetalaxm and ipatasertib. The hA1 subtype ...
The key enzyme in this pathway is the C–N-bond-cleaving glycyl radical enzyme (GRE) choline trimethylamine-lyase (CutC), which converts choline into TMA and acetaldehyde (Craciun et al., 2014). Bioinformatic analyses have revealed that choline utilization is prevalent in human stool ...
An implementation of an SBML solver that passes the test suite should in principle also be capable of computing the solution of all models from BioModels Database, a resource that contains a collection of published and curated models. This online database currently provides neither reference data ...
that in both LbUGT2 and LbUGT4 structures, the 4’-OH group of 2 forms a stable hydrogen bond with the catalytic histidine (H16 and H21) and is in close proximity to the acetal C atom of UDP-Glc, consistent with their glycosylation activity towards the 4-OH of the caffeoyl group. Not...
Structural optimization affording 2-(R)-(1-(R)-3, 5-bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazole-5-yl)methyl morpholine, a potent, orally active, long-acting morpholine acetal human NK-1 receptor antagonist. J. Med. Chem. 1998, 41, 4607–46...