The crystal structure of bis(acetylacetonato)lead(II) and the structure of the acetylacetone solvated lead(II) ion in solution have been determined by single-crystal X-ray diffraction and large-angle X-ray scattering (LAXS), respectively. The acetylacetone is deprotonated and acts as a bidentate...
Within this tunnel, catalytic histidine and asparagine approach the lumen and instigate the transfer of the acetyl group from Ac-CoA to the glucosamine group of HS. Our study unveils a transmembrane acetylation mechanism that may help advance therapeutic strategies targeting lysosomal storage diseases. ...
Pectins are plant cell wall polysaccharides that can be acetylated on C2 and/or C3 of galacturonic acid residues. The degree of acetylation of pectin can be modulated by pectin acetylesterase (EC 3.1.1.6, PAE). The function and structure of plant PAEs remain poorly understood and the role of...
In this article, the crystal structures of two novel Gd(Ⅲ) acetylacetonato complexes, Gd(pta)3·2H2O (pta=1,1,1-trifluoro-5,5-dimethyl-2,4-hexanedione) and Gd(bfa)3·2H2O (bfa=1, 1, 1-trifluoro-4-phenyl-2-4-butanedione) were reported. Though both of them were dihydrate and ...
The final step in the synthesis of 4-acetamido-4,6-dideoxy-D-galactose, the acetyl-coenzyme A (CoA)-dependent acetylation of the 4-amino group, is carried out by TDP-fucosamine acetyltransferase (WecD). We have determined the crystal structure of WecD in apo form at a 1.95-Angstroms ...
(YEATSSMARCD1) associates with SWIBSMARCD1and the coiled-coil of SMARCD1 in the Fingers. YEATSSMARCD1is organized into two parallel four-stranded β-sheets, as in other YEATS domains, but lacks a conserved acetyl-lysine binding pocket. As a peripheral domain, YEATSSMARCD1is positioned by as far...
A series of novel 2-[5-(aryloxyacetyl)-amino-1,3,4-thiadiazol-2-ylthio] propionate derivatives were synthesized in high yield, and their structures were characterized by IR, 1H NMR, 13C NMR, and elemental analysis, coupled with one selected single-crystal X-ray structure determination. The...
Rhamnogalacturonan acetylesterase from Aspergillus aculeatus (RGAE) has been shown to possess this specificity 2, 3, 4. Its action is a prerequisite for the lyases and hydrolases acting on the backbone glycosyl bonds of RG-I. At present, the structure is known for one of these enzymes, ...
During superheated steam processing, carbonic acids, mainly acetic acid, might initially be formed due to the cleavage of the acetyl groups of particular hemicelluloses17,18,19, leading to autocatalytic reactions of the cell wall constituents and an increase of relative crystallinity13,20. Lignin is...
5). Of note were signatures on chromosomes 10, 16, 17, and 22 occurring in genes associated with food/drug metabolism. We observed signals on chromosome 10 associated with missense variants on the ACSM6 gene associated with acetyl coenzyme-A production (p = 1.62 × 10−06), ...