Acetyl-CoA: Acetyl-CoA is a specific type of Acyl-CoA in which the acyl group is a two-carbon acetyl group (-COCH3). The acetyl group is attached to coenzyme A via a thioester bond, similar to other Acyl-CoAs. Role in Metabolic Pathways: Acyl-CoA: Acyl-CoAs serve as key intermedia...
U. et al. Acyl group migration and cleavage in selectively protected β-D-galactopyranosides as studied by NMR spectroscopy and kinetic calculations. J. Am. Chem. Soc. 130, 8769–8772 (2008). CAS PubMed Google Scholar Lassfolk, R. et al. Acetyl group migration across the saccharide ...
Samples were then desalted by cation exchange chromatography51 and prepared for analysis by pre-column derivatization with o-phthaldialdehyde/N-acetyl-L-cysteine (OPA/NAC)50. OPA/NAC is a chiral, fluorescent tag that enhances analytical sensitivity and specificity for primary amino groups and ...
phospholipase A2 group XVcrystallographycholesterolceramideselectivitypH dependenceLysosomal phospholipase A2 (LPLA 2 ) is characterized by broad substrate recognition, peak activity at acidic pH, and the transacylation of lipophilic alcohols, especially N -acetyl-sphingosine. Prior structural analysis of ...
PKSs. The key is to enhance the recognition of theACP(e.g., JamC) by PKSs whereas maintain the recognition of the ACP by the membrane bifunctional desaturase/acetylense. Meanwhile, the preference of downstream PKSs to the alkynyl acyl group is also important, in particular forin vivo...
Taken together, these results highlight that Acbp6 and acyl-CoA metabolism in midgut enterocytes can dictate general (pan-) lysine acetylation, correlated with changes in ISC proliferative homeostasis, by tuning acetyl-CoA metabolism during nutrient adaptation. Distinctively, Acbp6 induction is thus lin...
Any group or radical of the form RCO- where R is an organic group; An example of the acyl group is the acetyl group Alkyl Any of a series of univalent groups of the general formula CnH2n+1 derived from aliphatic hydrocarbons Common Curiosities What is the primary structural difference betw...
6. The derivative of claim 1 wherein the acyl group is acetyl. 7. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier. 8. A method of treating cancer in a mammal comprising administering to the mammal an effective cancer treatment amount of a...
most preferably phenyl or substituted phenyl; aralkyl, preferably (C6-10)ar(C1-6)alkyl, more preferably (C6-10)ar(C1-3)alkyl, most preferably benzyl or naphthylmethyl; acyl, preferably acetyl, benzoyl, or substituted benzoyl; heterocyclic radical, preferably heteroaryl or fused heteroaryl; and ...
2.The method of claim 1 wherein the N-acyl methionine whose accumulation is reduced is chosen among the following group: N-acetyl-methionine, N-propionyl-methionine, N-butyryl-methionine, and combinations thereof. 3.The method of claim 1 wherein said reduction of the accumulation of N-acyl ...