Thbs1处理后WT肝细胞中甘油三酯积累的减少或Thbs1处理后CD36 KO肝细胞中甘油三酯积累的不变,这表明CD36可能介导Thbs1对脂肪生成的抑制。ABT-526还可以剂量依赖性地抑制经高糖加胰岛素处理的WT原代肝细胞中SREBP-1的裂解以及FAS和SCD1的蛋白水平(图5e)。通过比色酶法测定,WT肝细胞中的拟肽ABT-526处理后甘油三酯积累...
Also, THBS1 was observed to interact with CD36, a membrane signal receptor and activator of the cAMP signaling pathway, to regulate the fusion of cytotrophoblast cells. Overexpression of THBS1 inhibited the cAMP signaling pathway and reduced the BeWo cells fusion ratio, while the effects of THB...
TSP1 interacts with no less than 12 cell adhesion receptors, including CD36, ?v integrins, ?1 integrins, syndecan, and integrin-associated protein (IAP or CD47). It also interacts with various proteases involved in angiogenesis, including plasminogen, urokinase, matrix metalloproteinase, thrombin, ...
CD47 and CD36 cell surface proteins were originally proposed to serve as Thbs1 receptors, where they mediate signaling associated with secreted extracellular Thbs111. While the field now understands that CD36 and CD47 are multiligand receptors with additional important functions in fatty acid transport...
although the extent of the increase was less than that in tumors inThbs1-/-mice (Fig.4b, c). Reflecting the difference in CD8+T cell infiltration, MTO-bearingCd47-/-andCd36-/-mice showed reduced liver metastases, although to a slightly lesser extent than MTO-bearingThbs1-/-mice (Fig....
摘要:近年来,在多种类型的肿瘤中均发现了血小板凝血酶蛋白G1(t h r o m b o s p o n d i n G1,T H B S 1)的异常表达,其是近年来肿瘤领域研究的热门靶点基因.T H B S 1作为一种多功能蛋白,在肿瘤中的作用较为复杂,对肿瘤的影响机制尚不完全明确,功能及调控机制有待进一步深入研究.现对...
adhesion,motility,and growth have been attributed to TSP1.This should not be surprising considering that TSP1 interacts with at least 12 cell adhesion receptors,including CD36,αv integrins,β1 integrins,syndecan,and integrin-associated protein (IAP or CD47).It also interacts with numerous ...
TSP-1是1971年由Baenziger等首次从血小板细胞膜中分离,由正常的纤维细胞、内皮细胞、平滑肌细胞、脑胶质细胞及膀胱上皮细胞等分泌,作用于膜受体CD36,并活化Fyn、Src酪氨酸激酶,内皮细胞。 |特异性 可检测样本中大鼠的THBS1,且与其类似物无明显交叉反应。
THBS1与淋巴管生长也有一定关系,其与单核细胞表面CD36结合后可抑制炎症诱导的淋巴管生长,并明显抑制淋巴管内皮细胞增殖和游走[15]。THBS4由于缺少TSRs序列,其抑制血管生成的作用较THBS1弱。研究表明,THBS4表达与MMP9表达密切相关,可促进肿瘤侵袭转移[16]。本研究免疫组化染色结果显示,THBS1和THBS4表达定位于细胞...
Type I TSP repeats interact with MMPs and CD36, while carboxy-terminal repeats bind the thrombospondin receptor CD47. Through these interactions, THBS1 exerts diverse effects on different signaling pathways, such as VEGF receptor/NO signaling, TGFβ signaling, and the NF-κB pathway. Thrombospondin...