Also, THBS1 was observed to interact with CD36, a membrane signal receptor and activator of the cAMP signaling pathway, to regulate the fusion of cytotrophoblast cells. Overexpression of THBS1 inhibited the cAMP signaling pathway and reduced the BeWo cells fusion ratio, while the effects of THB...
CD36是Thbs1抑制脂肪生成和肝细胞内过量甘油三酯储存作用所必需的,表明CD36是Thbs1抑制肝脂肪生成药理作用所必需的。尽管这些结果似乎与先前显示CD36缺陷小鼠脂肪生成基因表达降低的研究相矛盾[43],但CD36信号可能被不同激活,以增加或减少肝脏脂肪生成,从而响应不同的细胞配体或环境刺激。可以想象,肝脏脂肪含量可能由精...
当组织微环境稳定时，Thbs1通过激活TGF-β信号通路维持巨噬细胞的抗炎表型，促进组织修复。但在病理状态下，该基因会驱动巨噬细胞向促炎方向极化，例如在动脉粥样硬化斑块中，Thbs1过表达会促使巨噬细胞大量分泌基质金属蛋白酶，加速血管壁基质降解。研究显示Thbs1与CD36受体结合后，会触发巨噬细胞内NF-κB信号通路...
Based on other surveys, both CD36 and CD47 are required for OC differentiation and maturation and more interestingly, anti-THBS-1 antibodies completely suppress the differentiation of these cells. However, L-NAME treatment has been shown to rescue this inhibitory effect20. Based on the above-...
and growth have been attributed to TSP1.This should not be surprising considering that TSP1 interacts with at least 12 cell adhesion receptors,including CD36,αv integrins,β1 integrins,syndecan,and integrin-associated protein (IAP or CD47).It also interacts with numerous proteases involved in ...
THBS1 以其多受体结合而闻名,包括整合素和 CD36,调节与细胞粘附、迁移和存活相关的信号通路。THBS1 Protein, Mouse (His) 是重组的 THBS1 蛋白,由 E. coli 表达,带有 N-6*His 标签。THBS1 Protein, Mouse (His) 全长 332 个氨基酸,分子量为 40.6 kDa。 品牌介绍: MCE (MedChemExpress) 拥有数百种*...
4a). Tumors in Cd47-/- and Cd36-/- mice demonstrated increased CD8+ cell infiltration and apoptosis compared to those in WT mice, although the extent of the increase was less than that in tumors in Thbs1-/- mice (Fig. 4b, c). Reflecting the difference in CD8+ T cell infiltration, ...
2B). They expressed exosomal markers TSG101, CD81, and CD63, with no calnexin detected (Fig. 2C). Immunofluorescence staining confirmed that PKH67-labeled exosomes were internalized by HBMECs during the co-culture (Fig. 2D). Co-culture with AMφ-exo significantly decreased HBMEC survival ...
TSP-1是1971年由Baenziger等首次从血小板细胞膜中分离,由正常的纤维细胞、内皮细胞、平滑肌细胞、脑胶质细胞及膀胱上皮细胞等分泌,作用于膜受体CD36,并活化Fyn、Src酪氨酸激酶,内皮细胞。 |特异性 可检测样本中大鼠的THBS1,且与其类似物无明显交叉反应。
MiR-24 promotes cell growth in human glioma by CDX1/PI3K/Akt signaling pathway. Cancer Biother Radiopharm. 2021;36(7):588–99. 17. Han Y, Wang H. MiR-3918 inhibits tumorigenesis of Glioma via Targeting EGFR to regulate PI3K/AKT and ERK pathways. J Mol Neuroscience: MN. 2022;72(2):...