CD36是Thbs1抑制脂肪生成和肝细胞内过量甘油三酯储存作用所必需的,表明CD36是Thbs1抑制肝脂肪生成药理作用所必需的。尽管这些结果似乎与先前显示CD36缺陷小鼠脂肪生成基因表达降低的研究相矛盾[43],但CD36信号可能被不同激活,以增加或减少肝脏脂肪生成,从而响应不同的细胞配体或环境刺激。可以想象,肝脏脂肪含量可能由精...
Also, THBS1 was observed to interact with CD36, a membrane signal receptor and activator of the cAMP signaling pathway, to regulate the fusion of cytotrophoblast cells. Overexpression of THBS1 inhibited the cAMP signaling pathway and reduced the BeWo cells fusion ratio, while the effects of THB...
摘要:近年来,在多种类型的肿瘤中均发现了血小板凝血酶蛋白Ｇ１(t h r o m b o s p o n d i n Ｇ１,T H B S １)的异常表达,其是近年来肿瘤领域研究的热门靶点基因.T H B S １作为一种多功能蛋白,在肿瘤中的作用较为复杂,对肿瘤的影响机制尚不完全明确,功能及调控机制有待进一步深入研究.现对...
Based on other surveys, both CD36 and CD47 are required for OC differentiation and maturation and more interestingly, anti-THBS-1 antibodies completely suppress the differentiation of these cells. However, L-NAME treatment has been shown to rescue this inhibitory effect20. Based on the above-...
1g, h). In fact, loss of ATF6α, as well as loss of CD36, significantly enhanced the cardiomyopathic lethal phenotype associated with Thbs1 overexpression in the heart (Supplementary Fig. 1f, h). Thbs1 binds and activates a PERK-mediated ER-stress response Overexpression of Thbs1, 3, ...
TSP-1是1971年由Baenziger等首次从血小板细胞膜中分离,由正常的纤维细胞、内皮细胞、平滑肌细胞、脑胶质细胞及膀胱上皮细胞等分泌,作用于膜受体CD36,并活化Fyn、Src酪氨酸激酶,内皮细胞。 |特异性 可检测样本中大鼠的THBS1,且与其类似物无明显交叉反应。
and growth have been attributed to TSP1.This should not be surprising considering that TSP1 interacts with at least 12 cell adhesion receptors,including CD36,αv integrins,β1 integrins,syndecan,and integrin-associated protein (IAP or CD47).It also interacts with numerous proteases involved in ...
THBS1与淋巴管生长也有一定关系,其与单核细胞表面CD36结合后可抑制炎症诱导的淋巴管生长,并明显抑制淋巴管内皮细胞增殖和游走[15]。THBS4由于缺少TSRs序列,其抑制血管生成的作用较THBS1弱。研究表明,THBS4表达与MMP9表达密切相关,可促进肿瘤侵袭转移[16]。本研究免疫组化染色结果显示,THBS1和THBS4表达定位于细胞...
背景:介导细胞间和细胞间基质相互作用的粘附性糖蛋白。结合肝素。可能在牙本质形成和/或牙本质和牙髓的维持中起作用。CD36介导抗血管生成特性的配体 克隆性:多克隆抗体 运输和储存:Thbs1抗体在冰袋上运输,收到后应储存在-20或-80摄氏度。我们建议您提前准备工作等份,以避免freez解冻循环。不要将抗体暴露于直接强光...
4a). Tumors in Cd47-/- and Cd36-/- mice demonstrated increased CD8+ cell infiltration and apoptosis compared to those in WT mice, although the extent of the increase was less than that in tumors in Thbs1-/- mice (Fig. 4b, c). Reflecting the difference in CD8+ T cell infiltration, ...