W. et al. CD36 mediates the In vitro inhibitory effects of thrombospondin-1 on endothelial cells. J. Cell Biol. 138, 707–717 (1997). CAS PubMed PubMed Central Google Scholar Bagavandoss, P. & Wilks, J. W. Specific inhibition of endothelial cell proliferation by thrombospondin. ...
Based on other surveys, both CD36 and CD47 are required for OC differentiation and maturation and more interestingly, anti-THBS-1 antibodies completely suppress the differentiation of these cells. However, L-NAME treatment has been shown to rescue this inhibitory effect20. Based on the above-...
)作者简介:包楠丁,女,硕士.通讯作者:贾永峰.摘要:近年来,在多种类型的肿瘤中均发现了血小板凝血酶蛋白Ｇ１(t h r o m b o s p o n d i n Ｇ１,T H B S １)的异常表达,其是近年来肿瘤领域研究的热门靶点基因.T H B S １作为一种多功能蛋白,在肿瘤中的作用较为复杂,对肿瘤的影响机制尚不完全...
THBS1与淋巴管生长也有一定关系,其与单核细胞表面CD36结合后可抑制炎症诱导的淋巴管生长,并明显抑制淋巴管内皮细胞增殖和游走[15]。THBS4由于缺少TSRs序列,其抑制血管生成的作用较THBS1弱。研究表明,THBS4表达与MMP9表达密切相关,可促进肿瘤侵袭转移[16]。本研究免疫组化染色结果显示,THBS1和THBS4表达定位于细胞...
Deletion of Thbs1 effectors/receptors, including ATF6伪, CD36 or CD47 does not diminish Thbs1-dependent cardiac atrophy. However, deletion of the gene encoding PERK in Thbs1 transgenic mice blunts the induction of ATF4 and autophagy, and largely corrects the lethal cardiac atrophy. Finally, ...
CD47 and CD36 cell surface proteins were originally proposed to serve as Thbs1 receptors, where they mediate signaling associated with secreted extracellular Thbs111. While the field now understands that CD36 and CD47 are multiligand receptors with additional important functions in fatty acid transport...
Also, THBS1 was observed to interact with CD36, a membrane signal receptor and activator of the cAMP signaling pathway, to regulate the fusion of cytotrophoblast cells. Overexpression of THBS1 inhibited the cAMP signaling pathway and reduced the BeWo cells fusion ratio, while the effects of THB...
that THBS1 signals through a CD36-mediated cAMP pathway to regulate syncytialization of the cytotrophoblast cells,and that its upregulation impairs placental formation to cause preeclampsia.Thus,THBS1 can serve as a therapeutic target regarding the mitigation of abnormal syncytialization and preeclampsia...