a-thalassemias are characterized by decreased a chain synthesis. The most common defect is deletional, although non-deletional defects have been described. The a gene is duplicated, and there are 2 a globin genes per haploid genome; thus the abnormality can result from one to four gene deleti...
The thalassemia disorders are all characterized by a reduced rate of synthesis of 1 or more of the globin chains of hemoglobin. This abnormality usually results from partial or total reduction in the rate of production of normal globin chains, although there are now several forms of thalassemia ...
Inflammatory Mediators Are Increased in Leukocytes of IVS-I-6 (T→C) Homozygous β-Thalassemia Intermedia4068 Poster Board III-1003 Thalassemia is characterized by chronic inflammatory state and inflammation may play an important role in the pathogenesis of this diseases. Endothelial adhesion molecules,...
The thalassemias are a group of hemoglobin disorders characterized by a reduced synthesis of one or more of the globin chains (α, β, γ, δβ, γδβ, δ and εγδβ) and are the commonest monogenic disorders to cause a major public h... J Gaziev,G Lucarelli 被引量: 74发表:...
内容提示: 8.2 b-Thalassemia Major (Cooley’s Anemia) 293 8.2 b -Thalassemia Major (Cooley’s Anemia) b -thalassemia major is a hereditary hemolytic anemia, characterized by def i ciency in the hemoglobin beta chain synthesis. Patients with b -thalassemia major are prone to repeated attacks ...
BACKGROUND Thalassemia syndromes are inherited hemoglobin (Hb) disorders that most severely affect Southeast Asia (SEA). As a result of population migration, thalassemia has grown into a global health issue, posing challenges to health services in many host countries. However, little attention has b...
β-Thalassemia is a genetic hemolytic disorder characterized by diminished production of β-globin chains, attributable to alterations within coding and noncoding sequences of the β-globin gene (1). Whether noncoding mutations are invol... Leonid M Irenge,A Robert,Jean-Luc Gala - 《Clinical ...
beta-Thalassemia genes, although often mild in their effects, are common among American Blacks. We have begun a systematic molecular analysis of beta-thala... SE Antonarakis,SH Irkin,TC Cheng,... - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量:...
Abetalipoproteinemia (ABL; OMIM 200100) and homozygous hypobetalipoproteinemia (HHBL; OMIM 107730) are rare diseases characterized by hypocholesterolemia a... J Lee,RA Hegele - 《Journal of Inherited Metabolic Disease》 被引量: 76发表: 2014年 Abetalipoproteinemia and homozygous hypobetalipoprotei...
How to Avoid Thalassemia Thalassemia is an inherited blood disorder characterized by production of less hemoglobin (the protein in red blood cells that carries oxygen to cells thro... B Disease - 《Diabetes》 被引量: 0发表: 0年 The silent carrier of beta thalassemia. " A family of Albanian...