Introduction: Thalassemia which is also called as Cooley's anemia or Mediterranean anemia is a group of hereditary hemolytic anemia characterized by reduction in the synthesis of hemoglobin. The word 'thalassemia' is derived from the Greek word 'Thalassa' which means the great sea. Clinical ...
thal·as·se·mi·a (thăl′ə-sē′mē-ə) n. An inherited form of anemia occurring chiefly among people of Mediterranean descent, caused by faulty synthesis of part of the hemoglobin molecule. Also calledMediterranean anemia. [Greekthalassa,sea+-emia.] ...
and Southeast Asia. β-Thalassemia is especially common in areas such as northern Thailand, Laos, and Vietnam. In these areas, there are complex interactions between these disorders and Hb E, a β-chain variant that is also underexpressed, leading to a thalassemia-like phenotype. In Africa, ...
Thus, the diagnosis scheme combined with these two methods is only suitable for small-scale use. As the relevant knowledge of thalassemia spreads in Guangxi and Guangdong in China, the general public has attached great importance to thalassemia diagnosis and the number of common people who require...
The process is also referred to as “Bone Marrow Transplant.” In selected cases, it may be used to cure severe Thalassemia. Before this procedure, extremely high doses of radiation or drugs may be needed to destroy the diseased bone marrow in sufferers. Following this, patients may receive...
The meaning of THALASSEMIA is any of a group of inherited disorders of hemoglobin synthesis (such as Cooley's anemia) that are marked by mild to severe hypochromic and microcytic anemia, result from the partial or complete failure in production of one or
Two β-globins and two α-globins serve as a scaffold that holds four heme mole- cules with iron to form hemoglobin. The α-thalassemia carriers resulting from a deletion or dysfunction of one allele are also called "silent carriers" because the hematological profile is gen- erally entirely...
What is the difference between thalassemia minor and major? There are two forms of beta thalassemia. They are thalassemia minor and thalassemia major (which is also called Cooley's anemia). Thalassemia minor An individual with thalassemia minor has only one copy of the beta thalassemia gene (toge...
The term thalassemia is derived from the Greek, thalassa (sea) and haima (blood). Beta-thalassemia includes three main forms: Thalassemia Major, variably referred to as "Cooley's Anemia" and "Mediterranean Anemia", Thalassemia Intermedia and Thalassemia Minor also called "beta-thalassemia carrier"...
β-thalassemia minor(also calledβ-thalassemia trait) results when one β-globin gene is affected by a mutation that decreases or abolishes its expression, whereas the other β-globin gene is normal (heterozygous state). It usually presents as a mild, asymptomaticanemia, but thehemoglobin levelcan...