参考文献: [1]Harker JA, Lloyd CM. T helper 2 cells in asthma. J Exp Med. 2023;220(6):e20221094. [2]钱雪娇,蒋萍. 2型炎症型哮喘发病机制 [J]. 中华临床免疫和变态反应杂志, 2022, 16 (06): 629-635. [3]Castro M, Corren J...
5. Mutalithas K, Guillen C, Raport C, et al. Expression of CCR8 is increased in asthma[J]. Clin Exp Allergy 2010 Aug;40(8) 1175–1185. 6. Upadhyaya B, Yin Y, Hill BJ, et al. Hierarchical IL-5 expression defines a subpopulation of highly differentiated human Th2 cells[J]. J I...
These Th2 cells represent an attractive target for the treatment of asthma. The use of immunomodulators selective for disease-relevant T cells that do not affect the bulk of the lymphoid compartment would reduce the risk of side effects. We propose Kv1.3 potassium channel blockers for the ...
lling all TH2 cells Allergy and Asthma: Calling all TH2 cellsAllergy and Asthma: Calling all TH2 cellshumanCTLviralMHC class Iantigen presentation/processingThe article discusses papers which show that signals derived from basophils and eosinophils are directly involved in the induction of T helper...
Asthma represents a profound worldwide public health problem. The most effective anti-asthmatic drugs currently available include inhaled β2 -agonists and glucocorti-coids; these control asthma in about 90–95% of patients. However, the future therapies
7.Anatriello E, Cunha M, Nogueira J, et al. Oral feeding of Lactobacillus bulgaricus N45.10 inhibits the lung inflammation and airway remodeling in murine allergic asthma: Relevance to the Th1/Th2 cytokines and STAT6/T-bet...
Atopic asthma is a chronic inflammatory pulmonary disease characterised by recurrent episodes of wheezy, laboured breathing with an underlying Th2 cell-mediated inflammatory response in the airways. It is currently treated and, more or less, controlled d
Type 2 helper T cells (TH2) are critically involved in allergies and asthma. Here we demonstrate that extracellular matrix protein-1 (ECM1) is highly and selectively expressed in TH2 cells. ECM1 deficiency caused impaired TH2 responses and reduced allergic airway inflammation in vivo. Functional...
Asthma is a complex disease that is typically associated with T helper 2 (TH2)-type inflammation, but it is becoming increasingly clear that other T cell populations can contribute to the disease. Here, the authors describe the functions of distinct T ce
asthmachemokineshumanTh1/Th2CellsChemokines are involved not only in regulating leukocyte recruitment, but also in other activities. However, functions other than cell recruitment remain poorly understood. We have already shown that the production of CC chemokine ligand (CCL)17 and CCL22 by antigen-...