The measured NO expirogram was superimposed on the wallpaper (dotted line), to estimate the patient's NO production depth: H (% PDS) (Fig 1A&B).Results: We studied 7 treatment-nave (TN) asthma patients (FeNO 88±52ppb, mean±SD) and 10 patients on GINA 4 high-dose inhaled ...
Background: Asthma in children is usually considered a T2-high (T2H) atopic disease, yet the T2H non-atopic and T2-low (T2L) endotypes, seen in adults, have not been well defined in children.Aim: To investigate the expression of innate lymphoid cells-2 (ILC2), IL-4 and IL-5 in ...
doi:10.1183/13993003.00938-2018Stelios PavlidisKentaro TakahashiFrancois Ng Kee KwongJiaxing XieUruj HodaKai SunVahid ElyasigomariPaul AgapowMatthew LozaFred BaribaudEuropean Respiratory Society
severe asthmaventilation heterogeneityBackground Hyperpolarized gas with helium (HHe-3) MR (magnetic resonance) is a noninvasive imaging method which maps and quantifies regions of ventilation heterogeneity (VH) in the lung. VH is an important feature of asthma, but little is known as to how ...
Cydney RiosBrian O'ConnorJohn V FahyMax A SeiboldAm J Respir Crit Care MedPeters MC, Ringel L, Dyjack N, Herrin R, Woodruff PG, Rios C, et al. A transcriptomic method to determine airway immune dysfunction in T2-high and T2-low asthma. Am J Respir Crit Care Med 2019; 199:465-...
Eosinophils are central inflammatory cells in asthma; however, a portion of patients with chronic obstructive pulmonary disease (COPD) have blood or sputum eosinophilia, a condition termed eosinophilic COPD (eCOPD), which may contribute to the progression of the disease. We hypothesize that ...
Managing T2-high severe asthma in HIV-infected patientsdoi:10.1016/j.jaip.2020.11.015Milan TerlMilos JesenakThe Journal of Allergy and Clinical Immunology In Practice
severe asthmaventilation heterogeneityBackground Hyperpolarized gas with helium (HHe MR (magnetic resonance) is a noninvasive imaging method which maps and quantifies regions of ventilation heterogeneity (VH) in the lung. VH is an important feature of asthma, but little is known as to how VH ...
The method is applied to data from a German asthma family study. The results based on the paired Hotelling's T2 statistic tests confirm the previous findings. However, the paired Hotelling's T2 tests produce much smaller P‐values than those of the previous study. The permutation tests produce...
AsthmaChildrenAllergyIntroduction: Sex differences in childhood asthma, allergy, and atopic dermatitis have previously been described, but the development, clinical phenotype, and nature of these sex differences is not well understood. Therefore, we investigated sex differences in these diseases and ...